OR1F1
Olfactory Receptor Family 1 Subfamily F Member 1
Gene Information Card
| Symbol | OR1F1 |
|---|---|
| Full Name | Olfactory Receptor Family 1 Subfamily F Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 4990 ncbi.nlm.nih.gov/gene/4990 |
| Ensembl ID | ENSG00000196453 |
| UniProt ID | Q8NH84 |
| OMIM ID | 618474 |
| HGNC ID | 8190 |
| Aliases | OR1-1, OR1F1P, OR1F1Q, OR1F1R |
Description
OR1F1 (Olfactory Receptor Family 1 Subfamily F Member 1) is a protein-coding gene that belongs to the olfactory receptor family, a large group of G protein-coupled receptors (GPCRs) responsible for detecting odorants. The gene is located on chromosome 16p13.3 and encodes a 312-amino acid protein. Olfactory receptors are primarily expressed in the olfactory epithelium, where they bind odor molecules and initiate a neuronal response that leads to the perception of smell. OR1F1 is also expressed in non-olfactory tissues, suggesting potential roles beyond olfaction.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations reported | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Olfactory mucosa | 12.5 | Medium |
| Testis | 3.2 | Low |
| Brain (cerebellum) | 1.8 | Low |
| Lung | 0.9 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not detected |
| HepG2 | 0.0 | Not detected |
| A549 | 0.0 | Not detected |
| MCF7 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell | • plasma membrane |
Pathways
• Olfactory transduction (KEGG: hsa04740)
• GPCR downstream signaling
Protein Summary
OR1F1 encodes a 312-amino acid olfactory receptor protein with seven transmembrane domains, characteristic of GPCRs. It is involved in odorant binding and signal transduction via G protein activation. The protein is localized to the plasma membrane of olfactory sensory neurons.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR1F1 Knockout HEK293 Cell Line | EDJ-KQ5385 | Human | 4992 | Details Get a Quote |
| OR1F1 Knockout HeLa Cell Line | EDJ-KQ54053 | Human | 4992 | Details Get a Quote |
| OR1F1 Knockout A-549 Cell Line | EDJ-KQ62541 | Human | 4992 | Details Get a Quote |
| OR1F1 Knockout HCT 116 Cell Line | EDJ-KQ71013 | Human | 4992 | Details Get a Quote |
