OR1E1
Olfactory Receptor Family 1 Subfamily E Member 1
Gene Information Card
| Symbol | OR1E1 |
|---|---|
| Full Name | Olfactory Receptor Family 1 Subfamily E Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.2 |
| NCBI Gene ID | 8383 ncbi.nlm.nih.gov/gene/8383 |
| Ensembl ID | ENSG00000170579 |
| UniProt ID | P47884 |
| OMIM ID | 618377 |
| HGNC ID | 8192 |
| Aliases | OR1E1P, OR17-2, OR17-3, OR1E1Q |
Description
OR1E1 (Olfactory Receptor Family 1 Subfamily E Member 1) is a protein-coding gene that belongs to the G protein-coupled receptor (GPCR) superfamily, specifically the olfactory receptor family. These receptors are responsible for the detection of odorants in the nasal epithelium. OR1E1 is located on chromosome 17p13.2 and is expressed in olfactory mucosa as well as in some non-olfactory tissues, suggesting potential roles beyond olfaction. The encoded protein is a seven-transmembrane domain receptor that activates a G protein signaling cascade upon ligand binding.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations currently curated in ClinVar or OMIM | Not applicable | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Olfactory mucosa | Not available | High |
| Testis | Not available | Moderate |
| Prostate | Not available | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | Not available | Not detected |
| A549 | Not available | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell | • plasma membrane |
Pathways
• Olfactory transduction (KEGG: hsa04740)
• GPCR downstream signaling
Protein Summary
OR1E1 encodes a 312-amino acid olfactory receptor with seven transmembrane domains, typical of class A GPCRs. The protein is involved in odorant recognition and signal transduction via G protein activation. Its expression in non-olfactory tissues suggests possible chemosensory functions outside the nose.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR1E1 Knockout HEK293 Cell Line | EDJ-KQ6222 | Human | 8387 | Details Get a Quote |
| OR1E1 Knockout HeLa Cell Line | EDJ-KQ54894 | Human | 8387 | Details Get a Quote |
| OR1E1 Knockout A-549 Cell Line | EDJ-KQ63381 | Human | 8387 | Details Get a Quote |
| OR1E1 Knockout HCT 116 Cell Line | EDJ-KQ71849 | Human | 8387 | Details Get a Quote |
