OR1D2 Olfactory Receptor Family 1 Subfamily D Member 2
Olfactory receptor gene involved in odorant detection and signal transduction
Gene Information Card
| Symbol | OR1D2 |
|---|---|
| Full Name | Olfactory Receptor Family 1 Subfamily D Member 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.3 |
| NCBI Gene ID | 26696 ncbi.nlm.nih.gov/gene/26696 |
| Ensembl ID | ENSG00000172420 |
| UniProt ID | P34982 |
| OMIM ID | 164342 |
| HGNC ID | 8190 |
| Aliases | OR1D3, OR1D4, OR1D5, OR17-2, OR17-4, OR17-6, hg31, hg32, hg33 |
Description
OR1D2 (Olfactory Receptor Family 1 Subfamily D Member 2) is a protein-coding gene located on chromosome 17p13.3. It encodes a member of the olfactory receptor family, which are G protein-coupled receptors (GPCRs) responsible for detecting odorants in the nasal epithelium. The protein is involved in the sensory perception of smell and signal transduction via the cAMP pathway.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Nasal epithelium | 0.0 | Not detected |
| Olfactory mucosa | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | No expression |
| HeLa | 0.0 | No expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell | • plasma membrane |
| • signal transduction |
Pathways
• Olfactory transduction (KEGG: hsa04740)
• GPCR downstream signaling
Protein Summary
OR1D2 encodes a 312-amino acid olfactory receptor protein with seven transmembrane domains, characteristic of GPCRs. It is expressed in olfactory sensory neurons and binds odorant molecules, activating a G protein-mediated signaling cascade that leads to neuronal depolarization.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR1D2 Knockout HEK293 Cell Line | EDJ-KQ5384 | Human | 4991 | Details Get a Quote |
| OR1D2 Knockout HeLa Cell Line | EDJ-KQ54052 | Human | 4991 | Details Get a Quote |
| OR1D2 Knockout A-549 Cell Line | EDJ-KQ62540 | Human | 4991 | Details Get a Quote |
| OR1D2 Knockout HCT 116 Cell Line | EDJ-KQ71012 | Human | 4991 | Details Get a Quote |
