OR12D2
Olfactory Receptor Family 12 Subfamily D Member 2
Gene Information Card
| Symbol | OR12D2 |
|---|---|
| Full Name | Olfactory Receptor Family 12 Subfamily D Member 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 6p22.1 |
| NCBI Gene ID | 26534 ncbi.nlm.nih.gov/gene/26534 |
| Ensembl ID | ENSG00000204678 |
| UniProt ID | Q8NG97 |
| OMIM ID | Not assigned |
| HGNC ID | 14787 |
| Aliases | OR12-2, OR12D2P, OR12D2Q |
Description
OR12D2 is a member of the olfactory receptor gene family, which encodes G protein-coupled receptors (GPCRs) responsible for detecting odorants. These receptors are expressed in the olfactory epithelium and initiate a neuronal response that triggers the perception of smell. OR12D2 is located on chromosome 6p22.1 and is considered a functional protein-coding gene.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Olfactory mucosa | Not available | Not available |
| Testis | Not available | Not available |
| Skin | Not available | Not available |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line data available | Not available | Not available |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • olfactory receptor activity |
| • detection of chemical stimulus involved in sensory perception of smell | • plasma membrane |
Pathways
• Olfactory transduction (KEGG: hsa04740)
Protein Summary
OR12D2 is a 312-amino acid olfactory receptor protein belonging to the rhodopsin-like GPCR superfamily. It contains seven transmembrane domains and is predicted to bind odorant molecules, activating a G protein signaling cascade that leads to neuronal depolarization.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR12D2 Knockout HEK293 Cell Line | EDJ-KQ7840 | Human | 26529 | Details Get a Quote |
| OR12D2 Knockout HeLa Cell Line | EDJ-KQ55946 | Human | 26529 | Details Get a Quote |
| OR12D2 Knockout A-549 Cell Line | EDJ-KQ64433 | Human | 26529 | Details Get a Quote |
| OR12D2 Knockout HCT 116 Cell Line | EDJ-KQ72888 | Human | 26529 | Details Get a Quote |
