OR10Q1 Gene: Function, Expression, and Clinical Significance | Biomedical Database

OR10Q1 is a protein-coding gene that encodes an olfactory receptor belonging to the G protein-coupled receptor (GPCR) family. Olfactory receptors are primarily expressed in the olfactory epithelium and are involved in the detection of odorants, initiating a signaling cascade that leads to the perception of smell. The gene is located on chromosome 11q12.1 and is part of the olfactory receptor gene cluster. While its specific ligand is not fully characterized, it is presumed to function in chemosensory perception.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Olfactory transduction pathway (KEGG: hsa04740)

The OR10Q1 protein is a seven-transmembrane GPCR with a typical olfactory receptor structure. It is predicted to localize to the plasma membrane and participate in odorant binding and signal transduction via G protein activation. The protein sequence is approximately 320 amino acids long, with conserved motifs characteristic of olfactory receptors, including the DRY motif in the second intracellular loop and the MAY motif in the third transmembrane domain. Its exact ligand specificity remains unknown.