OR10J1 Gene: Function, Location, and Clinical Relevance | Biomedical SEO

OR10J1 is a human olfactory receptor gene that encodes a G-protein-coupled receptor (GPCR) involved in the detection of odorants. Olfactory receptors are expressed in the cilia of olfactory sensory neurons and initiate a signaling cascade that leads to the perception of smell. OR10J1 belongs to the olfactory receptor family 10, subfamily J, member 1. The gene is located on chromosome 1q23.2 and is part of a large cluster of olfactory receptor genes. While its specific odorant ligands are not fully characterized, it is presumed to play a role in chemosensory perception. The protein is a seven-transmembrane domain receptor that couples to G-proteins, typically Gαolf, to activate adenylyl cyclase and increase cAMP levels, ultimately opening cyclic nucleotide-gated channels and triggering neuronal depolarization.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Olfactory transduction pathway (KEGG: hsa04740)

OR10J1 is a 312-amino acid protein with a molecular weight of approximately 35 kDa. It features seven transmembrane alpha-helices characteristic of GPCRs. The protein is localized to the plasma membrane of olfactory cilia. Its function is to bind odorant molecules and activate G-proteins, initiating a signaling cascade that results in an action potential in the olfactory neuron. The specific odorants recognized by OR10J1 are not yet identified, but it is likely involved in detecting volatile chemicals. The protein has an extracellular N-terminus and an intracellular C-terminus, with conserved motifs typical of olfactory receptors, such as the DRY motif in the second intracellular loop and a glycosylation site in the N-terminus.