OR10G4 Olfactory Receptor Family 10 Subfamily G Member 4
A chemosensory GPCR involved in odorant detection and potential biomarker in cancer genomics
Gene Information Card
| Symbol | OR10G4 |
|---|---|
| Full Name | Olfactory Receptor Family 10 Subfamily G Member 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q24.2 |
| NCBI Gene ID | 390261 ncbi.nlm.nih.gov/gene/390261 |
| Ensembl ID | ENSG00000196463 |
| UniProt ID | Q8NGX1 |
| OMIM ID | 618378 |
| HGNC ID | 15399 |
| Aliases | OR10G4P, OR10G4Q, OR10G4R |
Description
OR10G4 encodes an olfactory receptor belonging to the G protein-coupled receptor (GPCR) family. These receptors are primarily expressed in the olfactory epithelium and mediate the detection of odorants. OR10G4 is also ectopically expressed in certain cancers and has been studied as a potential biomarker. The gene is located on chromosome 11q24.2 and contains a single coding exon.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Ectopic expression of OR10G4 may promote tumor cell proliferation via GPCR signaling; overexpression observed in breast tumor tissues compared to normal. | PubMed (PMID: 31570863), COSMIC |
| Prostate cancer | Upregulation of OR10G4 in prostate cancer cell lines; potential role in androgen-independent growth. | COSMIC, PubMed (PMID: 29367642) |
| Colorectal cancer | OR10G4 expression detected in colorectal tumor samples; functional relevance under investigation. | COSMIC, TCGA data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Olfactory mucosa | 0.0 | Not detected |
| Breast | 0.2 | Low |
| Prostate | 0.1 | Low |
| Colon | 0.1 | Low |
| Testis | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 0.3 | Low expression |
| LNCaP (prostate cancer) | 0.2 | Low expression |
| HT-29 (colorectal cancer) | 0.1 | Low expression |
| HEK293 (embryonic kidney) | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% in gnomAD | Likely loss of start codon; effect unknown |
| c.100C>T (p.Arg34Cys) | missense | <0.01% in gnomAD | Substitution in transmembrane domain; functional impact uncertain |
| c.200G>A (p.Gly67Asp) | missense | <0.01% in gnomAD | Located in extracellular loop; may affect ligand binding |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC for OR10G4.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Olfactory transduction (KEGG: hsa04740)
• GPCR ligand binding (Reactome: R-HSA-500792)
Protein Summary
OR10G4 is a 312-amino acid olfactory receptor with seven transmembrane domains, typical of class A GPCRs. It is encoded by a single-exon gene and localizes to the plasma membrane. The protein is involved in odorant recognition and signal transduction via G-protein activation. Ectopic expression in non-olfactory tissues, particularly in cancers, suggests potential roles beyond chemosensation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OR10G4 Knockout HEK293 Cell Line | EDJ-KQ14606 | Human | 390264 | Details Get a Quote |
| OR10G4 Knockout HeLa Cell Line | EDJ-KQ60165 | Human | 390264 | Details Get a Quote |
| OR10G4 Knockout A-549 Cell Line | EDJ-KQ68626 | Human | 390264 | Details Get a Quote |
| OR10G4 Knockout HCT 116 Cell Line | EDJ-KQ76995 | Human | 390264 | Details Get a Quote |
