OPRPN Gene: Opiorphin Prepropeptide
Gene encoding the precursor of opiorphin, a potent endogenous inhibitor of enkephalin-inactivating peptidases.
Gene Information Card
| Symbol | OPRPN |
|---|---|
| Full Name | Opiorphin Prepropeptide |
| Gene Type | protein-coding |
| Chromosomal Location | 12q13.3 |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000204149 |
| UniProt ID | Q6UWK7 |
| OMIM ID | 617300 |
| HGNC ID | 44058 |
| Aliases | PROL1, PROL1-like, bA203J24.7 |
Description
OPRPN (Opiorphin Prepropeptide) is a protein-coding gene located on chromosome 12q13.3. It encodes the precursor of opiorphin, a naturally occurring peptide that inhibits enkephalin-inactivating peptidases (neutral endopeptidase and aminopeptidase N), thereby potentiating endogenous opioid signaling. OPRPN is predominantly expressed in salivary glands and is involved in pain modulation, stress response, and possibly oral mucosal protection.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Chronic Pain Disorders | Opiorphin deficiency may reduce endogenous analgesia; OPRPN polymorphisms associated with altered pain sensitivity. | PMID: 16916644, ClinVar |
| Oral Mucositis | Altered OPRPN expression in salivary glands may affect mucosal healing. | PMID: 21536856 |
| Depression | Opiorphin levels correlate with mood; potential biomarker for depressive states. | PMID: 20064382 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Salivary Gland | 112.3 | High |
| Esophagus | 8.2 | Low |
| Skin | 3.1 | Low |
| Lung | 1.5 | Not detected |
| Brain | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HSG (submandibular gland) | 45.6 | High expression |
| A549 (lung) | 0.3 | Very low |
| HEK293 (embryonic kidney) | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon; predicted loss of function |
| c.124C>T (p.Arg42Cys) | Missense | <0.01% | Uncertain significance; may affect peptide processing |
Mutation functional classification
Loss of Function (LOF)
Start codon loss (p.Met1?) likely abolishes translation.
Gain of Function (GOF)
No gain-of-function variants reported.
Dominant Negative (DN)
No dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • extracellular space (GO:0005615) |
| • peptidase inhibitor activity (GO:0030414) | • peptide catabolic process (GO:0043171) |
| • response to pain (GO:0048265) |
Pathways
• Opioid signaling pathway (Reactome: R-HSA-418594)
• Peptide hormone metabolism (Reactome: R-HSA-422085)
Protein Summary
The OPRPN gene encodes the prepropeptide of opiorphin, a 5-amino-acid peptide (QRFSR) that acts as a potent inhibitor of neutral endopeptidase (NEP) and aminopeptidase N (APN). By blocking the degradation of enkephalins, opiorphin enhances endogenous opioid tone, providing analgesic and antidepressant-like effects. The protein is secreted into saliva and other bodily fluids.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OPRPN Knockout HEK293 Cell Line | EDJ-KQ14568 | Human | 58503 | Details Get a Quote |
| OPRPN Knockout HeLa Cell Line | EDJ-KQ56943 | Human | 58503 | Details Get a Quote |
| OPRPN Knockout A-549 Cell Line | EDJ-KQ65449 | Human | 58503 | Details Get a Quote |
| OPRPN Knockout HCT 116 Cell Line | EDJ-KQ73886 | Human | 58503 | Details Get a Quote |
