OPRD1
Opioid Receptor Delta 1
Gene Information Card
| Symbol | OPRD1 |
|---|---|
| Full Name | Opioid Receptor Delta 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 4985 ncbi.nlm.nih.gov/gene/4985 |
| Ensembl ID | ENSG00000116329 |
| UniProt ID | P41143 |
| OMIM ID | 165195 |
| HGNC ID | 8155 |
| Aliases | DOR, OPRD, DOR1, delta opioid receptor |
Description
OPRD1 encodes the delta opioid receptor (DOR), a G protein-coupled receptor (GPCR) that binds endogenous opioid peptides such as enkephalins and beta-endorphin. It mediates analgesic, antidepressant, and anxiolytic effects, and modulates pain perception, mood, and reward pathways. The receptor is primarily expressed in the central nervous system and peripheral sensory neurons.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Chronic Pain | Altered receptor signaling reduces analgesic efficacy | ClinVar, NCBI |
| Major Depressive Disorder | Polymorphisms in OPRD1 affect mood regulation | ClinVar, PubMed |
| Substance Use Disorder | Variants influence opioid and alcohol dependence risk | ClinVar, NCBI |
| Epilepsy | DOR activation modulates seizure susceptibility | OMIM, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Spinal Cord | 8.3 | Medium |
| Adrenal Gland | 4.1 | Low |
| Testis | 2.7 | Low |
| Placenta | 1.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 15.2 | Neuroblastoma cell line |
| SK-N-SH | 12.8 | Neuroblastoma cell line |
| HEK293 | 0.5 | Low endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs2234918 (T307C) | Missense | 0.15 (global) | Altered ligand binding affinity |
| rs1042114 (F27C) | Missense | 0.08 | Reduced receptor expression |
| c.921C>T (p.Ser307Phe) | Missense | Rare | Impaired G protein coupling |
Mutation functional classification
Loss of Function (LOF)
Missense variants (e.g., Ser307Phe) reduce receptor activation and downstream signaling.
Gain of Function (GOF)
Not well documented; some variants may enhance agonist potency.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • opioid receptor activity |
| • signal transduction | • adenylate cyclase inhibition |
| • neurotransmitter receptor activity |
Pathways
• Opioid signaling pathway
• GPCR downstream signaling
• cAMP inhibition pathway
• MAPK signaling
Protein Summary
The delta opioid receptor (DOR) is a 372-amino acid transmembrane protein with seven alpha-helical domains. It couples primarily to Gi/o proteins, inhibiting adenylyl cyclase and modulating ion channels. DOR is involved in pain modulation, emotional behavior, and neuroprotection. Its structure and function are critical for developing targeted analgesics with reduced side effects.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OPRD1 Knockout HEK293 Cell Line | EDJ-KQ1099 | Human | 4985 | Details Get a Quote |
| OPRD1 Knockout HeLa Cell Line | EDJ-KQ54047 | Human | 4985 | Details Get a Quote |
| OPRD1 Knockout A-549 Cell Line | EDJ-KQ62535 | Human | 4985 | Details Get a Quote |
| OPRD1 Knockout HCT 116 Cell Line | EDJ-KQ71007 | Human | 4985 | Details Get a Quote |
