OMP (Olfactory Marker Protein) Gene
A key gene in olfactory sensory neuron function and potential biomarker in cancer
Gene Information Card
| Symbol | OMP |
|---|---|
| Full Name | Olfactory Marker Protein |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.5 |
| NCBI Gene ID | 4975 ncbi.nlm.nih.gov/gene/4975 |
| Ensembl ID | ENSG00000148773 |
| UniProt ID | P47874 |
| OMIM ID | 164340 |
| HGNC ID | 8136 |
| Aliases | OMP |
Description
The OMP gene encodes olfactory marker protein, a cytoplasmic protein specifically expressed in mature olfactory sensory neurons. It is involved in olfactory signal transduction and neuronal maturation. OMP is also ectopically expressed in certain cancers and has been investigated as a biomarker.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Olfactory dysfunction | Altered OMP expression may impair olfactory signaling | PMID: 10725237 |
| Colorectal cancer | Ectopic OMP expression in tumor tissue; potential biomarker | PMID: 25605247 |
| Prostate cancer | OMP expression detected in prostate cancer cell lines | PMID: 17317867 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Olfactory mucosa | — | High |
| Brain (cerebellum) | — | Not detected |
| Colon | — | Low |
| Prostate | — | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | — | Not detected |
| LNCaP (prostate cancer) | — | Detected |
| HCT116 (colorectal cancer) | — | Detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.100C>T | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • odorant binding (GO:0005549) | • sensory perception of smell (GO:0007608) |
| • neuron projection development (GO:0031175) | • cytoplasm (GO:0005737) |
Pathways
• Olfactory transduction pathway (KEGG: hsa04740)
Protein Summary
Olfactory marker protein (OMP) is a 19 kDa cytoplasmic protein predominantly expressed in mature olfactory sensory neurons. It modulates olfactory signal transduction by interacting with adenylyl cyclase and cyclic nucleotide-gated channels. OMP is also ectopically expressed in several cancers, suggesting a role beyond olfaction.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OMP Knockout HEK293 Cell Line | EDJ-KQ5380 | Human | 4975 | Details Get a Quote |
| OMP Knockout HeLa Cell Line | EDJ-KQ54043 | Human | 4975 | Details Get a Quote |
| OMP Knockout A-549 Cell Line | EDJ-KQ62531 | Human | 4975 | Details Get a Quote |
| OMP Knockout HCT 116 Cell Line | EDJ-KQ71003 | Human | 4975 | Details Get a Quote |
