OLAH (Oleoyl-ACP Hydrolase) Gene
Comprehensive gene card for OLAH, including genomic context, expression, and disease associations.
Gene Information Card
| Symbol | OLAH |
|---|---|
| Full Name | Oleoyl-ACP Hydrolase |
| Gene Type | protein-coding |
| Chromosomal Location | 10p13 |
| NCBI Gene ID | 114026 ncbi.nlm.nih.gov/gene/114026 |
| Ensembl ID | ENSG00000120071 |
| UniProt ID | Q9NYG1 |
| OMIM ID | 609288 |
| HGNC ID | 18707 |
| Aliases | MGC13170, dJ434O11.1 |
Description
OLAH encodes oleoyl-ACP hydrolase, an enzyme involved in fatty acid biosynthesis. It catalyzes the hydrolysis of oleoyl-acyl carrier protein (ACP) to free oleic acid and ACP, playing a role in lipid metabolism. The gene is located on chromosome 10p13 and is primarily expressed in certain tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 5.2 | Low |
| Liver | 3.8 | Low |
| Breast | 2.1 | Low |
| Testis | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 4.0 | Hepatocellular carcinoma cell line |
| MCF7 | 2.5 | Breast cancer cell line |
| A549 | 1.8 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants.
Gain of Function (GOF)
No documented gain-of-function variants.
Dominant Negative (DN)
No documented dominant-negative variants.
View complete mutation data：
Gene Ontology (GO)
| • oleoyl-[acyl-carrier-protein] hydrolase activity (GO:0016290) | • fatty acid biosynthetic process (GO:0006633) |
| • cytoplasm (GO:0005737) |
Pathways
• Fatty acid biosynthesis (Reactome: R-HSA-75105)
Protein Summary
Oleoyl-ACP hydrolase is a 305-amino acid protein localized to the cytoplasm. It specifically removes the oleoyl group from acyl carrier protein, releasing free oleic acid. This enzyme is involved in the termination step of fatty acid synthesis, contributing to cellular lipid homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OLAH Knockout HEK293 Cell Line | EDJ-KQ14559 | Human | 55301 | Details Get a Quote |
| OLAH Knockout HeLa Cell Line | EDJ-KQ56574 | Human | 55301 | Details Get a Quote |
| OLAH Knockout A-549 Cell Line | EDJ-KQ65070 | Human | 55301 | Details Get a Quote |
| OLAH Knockout HCT 116 Cell Line | EDJ-KQ73514 | Human | 55301 | Details Get a Quote |
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