OGFRL1
Opioid Growth Factor Receptor Like 1
Gene Information Card
| Symbol | OGFRL1 |
|---|---|
| Full Name | Opioid Growth Factor Receptor Like 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 6q22.31 |
| NCBI Gene ID | 79627 ncbi.nlm.nih.gov/gene/79627 |
| Ensembl ID | ENSG00000112406 |
| UniProt ID | Q5T7M9 |
| OMIM ID | 616064 |
| HGNC ID | 25526 |
| Aliases | OGFR-AS1, FLJ22662 |
Description
OGFRL1 (Opioid Growth Factor Receptor Like 1) is a protein-coding gene located on chromosome 6q22.31. It encodes a receptor-like protein that is structurally similar to the opioid growth factor receptor (OGFR). OGFRL1 is involved in cell growth regulation and may play a role in the opioid growth factor signaling pathway. Expression data suggest broad tissue distribution with highest levels in the brain and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association confirmed | Not established | No evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 10.8 | Medium |
| Lung | 6.2 | Low |
| Liver | 4.1 | Low |
| Kidney | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.3 | Moderate expression |
| HeLa | 5.7 | Low expression |
| K562 | 4.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional effect |
| c.250G>A (p.Gly84Ser) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005886 (GO:0005886) | • GO:0016021 (GO:0016021) |
| • GO:0007165 (GO:0007165) |
Pathways
• Opioid growth factor receptor signaling pathway (inferred)
Protein Summary
OGFRL1 encodes a 339-amino acid protein with a predicted transmembrane domain. The protein shares homology with OGFR and may function as a receptor for opioid growth factors, modulating cell proliferation. Its precise biological role remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OGFRL1 Knockout HEK293 Cell Line | EDJ-KQ14558 | Human | 79627 | Details Get a Quote |
| OGFRL1 Knockout A-549 Cell Line | EDJ-KQ44853 | Human | 79627 | Details Get a Quote |
| OGFRL1 Knockout HCT 116 Cell Line | EDJ-KQ44854 | Human | 79627 | Details Get a Quote |
| OGFRL1 Knockout HeLa Cell Line | EDJ-KQ44855 | Human | 79627 | Details Get a Quote |
