OGFR (Opioid Growth Factor Receptor)
A transmembrane receptor involved in cell cycle regulation and opioid growth factor signaling
Gene Information Card
| Symbol | OGFR |
|---|---|
| Full Name | Opioid Growth Factor Receptor |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.33 |
| NCBI Gene ID | 11054 ncbi.nlm.nih.gov/gene/11054 |
| Ensembl ID | ENSG00000101204 |
| UniProt ID | Q9NZT2 |
| OMIM ID | 606459 |
| HGNC ID | 8126 |
| Aliases | OGFr, OGF-R, ZOGFR |
Description
OGFR encodes the opioid growth factor receptor, a transmembrane protein that binds the opioid growth factor (OGF, Met-enkephalin). This receptor mediates the inhibitory effects of OGF on cell proliferation, particularly in epithelial and neural tissues. OGFR signaling is implicated in cell cycle regulation, tumor suppression, and wound healing. The gene is located on chromosome 20q13.33 and is expressed in a wide range of tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatic Cancer | OGFR downregulation reduces OGF-mediated growth inhibition, promoting tumor proliferation | PMID: 19029980 |
| Head and Neck Squamous Cell Carcinoma | Reduced OGFR expression correlates with loss of OGF antiproliferative signaling | PMID: 15607977 |
| Colorectal Cancer | OGFR expression is decreased in tumors, associated with poor prognosis | PMID: 20043216 |
| Corneal Wound Healing | OGFR activation by OGF delays re-epithelialization; receptor blockade accelerates healing | PMID: 15208134 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Pancreas | 15.2 | Medium |
| Colon | 11.4 | Medium |
| Skin | 7.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | Embryonic kidney |
| HeLa | 8.9 | Cervical carcinoma |
| MCF7 | 7.5 | Breast cancer |
| A549 | 6.3 | Lung cancer |
| PANC-1 | 12.1 | Pancreatic cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.104C>T (p.Pro35Leu) | Missense | <0.01% | Unknown functional impact |
| c.457G>A (p.Val153Ile) | Missense | <0.01% | Unknown functional impact |
| c.788A>G (p.Asn263Ser) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • protein binding (GO:0005515) |
| • signal transduction (GO:0007165) | • cell population proliferation (GO:0008283) |
| • integral component of membrane (GO:0016021) |
Pathways
• Opioid Growth Factor (OGF) signaling pathway
• Negative regulation of cell cycle
Protein Summary
The opioid growth factor receptor (OGFR) is a 677-amino acid transmembrane protein with an extracellular domain that binds Met-enkephalin (OGF). Upon ligand binding, OGFR activates a signaling cascade that leads to upregulation of cyclin-dependent kinase inhibitors (e.g., p21, p16) and G1/S cell cycle arrest. OGFR is widely expressed in normal tissues but frequently downregulated in cancers, suggesting a tumor suppressor role. The receptor is also involved in neural development and corneal epithelial homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OGFR Knockout HEK293 Cell Line | EDJ-KQ2757 | Human | 11054 | Details Get a Quote |
| OGFRL1 Knockout HEK293 Cell Line | EDJ-KQ14558 | Human | 79627 | Details Get a Quote |
| OGFRL1 Knockout A-549 Cell Line | EDJ-KQ44853 | Human | 79627 | Details Get a Quote |
| OGFRL1 Knockout HCT 116 Cell Line | EDJ-KQ44854 | Human | 79627 | Details Get a Quote |
| OGFRL1 Knockout HeLa Cell Line | EDJ-KQ44855 | Human | 79627 | Details Get a Quote |
| OGFR Knockout A-549 Cell Line | EDJ-KQ23655 | Human | 11054 | Details Get a Quote |
| OGFR Knockout HCT 116 Cell Line | EDJ-KQ23656 | Human | 11054 | Details Get a Quote |
| OGFR Knockout HeLa Cell Line | EDJ-KQ23657 | Human | 11054 | Details Get a Quote |
