ODAM Gene (Odontogenic, Ameloblast-Associated)
A key gene in tooth development and potential tumor suppressor
Gene Information Card
| Symbol | ODAM |
|---|---|
| Full Name | Odontogenic, Ameloblast-Associated |
| Gene Type | Protein coding |
| Chromosomal Location | 4q13.3 |
| NCBI Gene ID | 54959 ncbi.nlm.nih.gov/gene/54959 |
| Ensembl ID | ENSG00000109270 |
| UniProt ID | Q9BQ04 |
| OMIM ID | 614862 |
| HGNC ID | 25299 |
| Aliases | APin, C20orf42, bA163M19.1, dJ1009E24.1 |
Description
ODAM (Odontogenic, Ameloblast-Associated) encodes a secreted protein that is primarily expressed in ameloblasts during tooth development. It is involved in enamel formation and mineralization. ODAM has also been implicated in tumor suppression, with reduced expression observed in several cancers, including breast and lung cancer. The protein may play a role in cell adhesion and extracellular matrix organization.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Ameloblastoma | ODAM expression is altered in ameloblastoma, a benign odontogenic tumor, suggesting a role in tumorigenesis. | PubMed: 20673889 |
| Breast Cancer | Reduced ODAM expression is associated with poor prognosis and may act as a tumor suppressor. | PubMed: 23542377 |
| Lung Cancer | ODAM downregulation is observed in non-small cell lung cancer and correlates with metastasis. | PubMed: 25242534 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Salivary gland | 12.5 | Medium |
| Thyroid | 8.2 | Medium |
| Adrenal gland | 6.1 | Low |
| Testis | 5.3 | Low |
| Lung | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (Lung) | 1.5 | Low expression |
| MCF7 (Breast) | 0.8 | Very low |
| HepG2 (Liver) | 0.3 | Not detected |
| K562 (Leukemia) | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon, unknown effect |
| c.202C>T (p.Arg68Trp) | Missense | <0.01% | Unknown |
| c.364G>A (p.Gly122Ser) | Missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • cell adhesion (GO:0007155) |
| • bone mineralization (GO:0030282) | • odontogenesis of dentin-containing tooth (GO:0042475) |
| • enamel mineralization (GO:0070166) |
Pathways
• Tooth development (Reactome: R-HSA-425393)
• Extracellular matrix organization (Reactome: R-HSA-1474244)
Protein Summary
The ODAM protein is a secreted, extracellular matrix-associated protein of 279 amino acids. It contains a signal peptide and is involved in enamel biomineralization. The protein is also implicated in cell adhesion and may function as a tumor suppressor in epithelial cancers. Its expression is largely restricted to odontogenic tissues and certain glandular epithelia.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ODAM Knockout HEK293 Cell Line | EDJ-KQ13792 | Human | 54959 | Details Get a Quote |
| ODAM Knockout HeLa Cell Line | EDJ-KQ44836 | Human | 54959 | Details Get a Quote |
| ODAM Knockout A-549 Cell Line | EDJ-KQ65002 | Human | 54959 | Details Get a Quote |
| ODAM Knockout HCT 116 Cell Line | EDJ-KQ73446 | Human | 54959 | Details Get a Quote |
