OAZ2: Ornithine Decarboxylase Antizyme 2
A key regulator of polyamine homeostasis with implications in cancer and cell proliferation
Gene Information Card
| Symbol | OAZ2 |
|---|---|
| Full Name | Ornithine Decarboxylase Antizyme 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q22.31 |
| NCBI Gene ID | 4947 ncbi.nlm.nih.gov/gene/4947 |
| Ensembl ID | ENSG00000137807 |
| UniProt ID | O95190 |
| OMIM ID | 601579 |
| HGNC ID | 8096 |
| Aliases | AZ2, ODC-Az2 |
Description
OAZ2 encodes ornithine decarboxylase antizyme 2, a protein that negatively regulates polyamine biosynthesis by binding to ornithine decarboxylase (ODC) and targeting it for ubiquitin-independent proteasomal degradation. It also inhibits polyamine uptake and is involved in cell cycle regulation and apoptosis. Expression is induced by high polyamine levels via a unique ribosomal frameshifting mechanism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Altered OAZ2 expression may disrupt polyamine homeostasis, promoting cell proliferation | COSMIC; PMID: 23542377 |
| Colorectal cancer | Reduced OAZ2 levels correlate with increased ODC activity and tumor progression | NCBI Gene; PMID: 19074885 |
| Breast cancer | Dysregulation of antizyme family members, including OAZ2, affects polyamine-dependent growth | UniProt; PMID: 21558396 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Liver | 6.1 | Low |
| Kidney | 5.4 | Low |
| Heart | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 9.3 | Cervical cancer cell line |
| HEK 293 | 7.8 | Embryonic kidney cells |
| MCF7 | 6.5 | Breast cancer cell line |
| HepG2 | 5.9 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.307C>T (p.Arg103Trp) | Missense | <0.01% | Unknown functional impact; rare population variant |
| c.458A>G (p.Asn153Ser) | Missense | <0.01% | Unknown functional impact; rare population variant |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • enzyme inhibitor activity (GO:0004857) | • protein binding (GO:0005515) |
| • polyamine metabolic process (GO:0006595) | • proteasomal protein catabolic process (GO:0010498) |
| • cellular protein localization (GO:0034613) |
Pathways
• Polyamine metabolism (Reactome: R-HSA-351202)
• Regulation of ornithine decarboxylase (ODC) (KEGG: hsa00330)
Protein Summary
OAZ2 is a 228-amino acid protein (UniProt O95190) that functions as an antizyme, binding to ornithine decarboxylase (ODC) to inhibit its enzymatic activity and promote its degradation. It also inhibits polyamine transport. The protein is expressed in multiple tissues, with highest levels in testis. Its activity is regulated by polyamine-induced ribosomal frameshifting.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OAZ2 Knockout HEK293 Cell Line | EDJ-KQ5372 | Human | 4947 | Details Get a Quote |
| OAZ2 Knockout A-549 Cell Line | EDJ-KQ28504 | Human | 4947 | Details Get a Quote |
| OAZ2 Knockout HCT 116 Cell Line | EDJ-KQ28505 | Human | 4947 | Details Get a Quote |
| OAZ2 Knockout HeLa Cell Line | EDJ-KQ28506 | Human | 4947 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
