OAZ1 Gene - Ornithine Decarboxylase Antizyme 1
Key regulator of polyamine biosynthesis and cellular proliferation
Gene Information Card
| Symbol | OAZ1 |
|---|---|
| Full Name | Ornithine Decarboxylase Antizyme 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 4946 ncbi.nlm.nih.gov/gene/4946 |
| Ensembl ID | ENSG00000104904 |
| UniProt ID | P54368 |
| OMIM ID | 601579 |
| HGNC ID | 8095 |
| Aliases | AZ, OAZ, ODC1, antizyme 1 |
Description
OAZ1 encodes ornithine decarboxylase antizyme 1, a protein that negatively regulates polyamine biosynthesis by binding to ornithine decarboxylase (ODC1) and targeting it for ubiquitin-independent proteasomal degradation. It also inhibits polyamine uptake and is itself regulated by polyamine levels through a unique +1 ribosomal frameshift mechanism. OAZ1 plays a critical role in cell growth, differentiation, and apoptosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | OAZ1 downregulation leads to increased ODC1 activity and polyamine accumulation, promoting cell proliferation | PMID: 10652318 |
| Colorectal cancer | Reduced OAZ1 expression correlates with elevated polyamine levels and tumor progression | PMID: 11592034 |
| Gastric cancer | OAZ1 loss contributes to ODC1 overexpression and enhanced cell growth | PMID: 15604205 |
| Neuroblastoma | OAZ1 frameshift mutations impair antizyme function, increasing polyamine synthesis | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Liver | 8.3 | Medium |
| Kidney | 7.1 | Medium |
| Brain | 5.6 | Low |
| Heart | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | High expression |
| HeLa | 8.9 | Medium expression |
| MCF7 | 6.5 | Medium expression |
| A549 | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | 0.01% | Reduced protein stability |
| c.123_124insA | Frameshift | 0.05% | Loss of function |
| c.456C>T | Nonsense | 0.02% | Premature truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations impair OAZ1's ability to degrade ODC1, leading to polyamine excess.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • polyamine biosynthetic process (GO:0006596) |
| • cytosol (GO:0019858) | • protein catabolic process (GO:0030163) |
| • ribosome binding (GO:0043021) |
Pathways
• Polyamine metabolism (Reactome: R-HSA-351202)
• Regulation of ornithine decarboxylase (KEGG: hsa00330)
Protein Summary
OAZ1 is a 228-amino acid protein that functions as an antizyme, inhibiting ornithine decarboxylase (ODC1) and polyamine transport. It is induced by polyamines via a ribosomal frameshift and is degraded by the proteasome. OAZ1 is widely expressed, with highest levels in testis and liver. Loss of function contributes to polyamine dysregulation in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| OAZ1 Knockout HEK293 Cell Line | EDJ-KQ2507 | Human | 4946 | Details Get a Quote |
| OAZ1 Knockout HCT 116 Cell Line | EDJ-KQ23106 | Human | 4946 | Details Get a Quote |
| OAZ1 Knockout HeLa Cell Line | EDJ-KQ23107 | Human | 4946 | Details Get a Quote |
| OAZ1 Knockout A-549 Cell Line | EDJ-KQ21743 | Human | 4946 | Details Get a Quote |
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