NYNRIN Gene
NYN Domain and Retroviral Integrase Containing Gene
Gene Information Card
| Symbol | NYNRIN |
|---|---|
| Full Name | NYN domain and retroviral integrase containing |
| Gene Type | Protein coding |
| Chromosomal Location | 14q32.12 |
| NCBI Gene ID | 57523 ncbi.nlm.nih.gov/gene/57523 |
| Ensembl ID | ENSG00000100811 |
| UniProt ID | Q9H6U6 |
| OMIM ID | 616521 |
| HGNC ID | 26478 |
| Aliases | FLJ10707, NYN, NYN domain containing, retroviral integrase containing |
Description
NYNRIN is a protein-coding gene located on chromosome 14q32.12. It encodes a protein containing an NYN (NEDD4-BP1, YacP nuclease) domain and a retroviral integrase-like domain. The NYN domain is associated with nuclease activity, while the integrase domain suggests potential involvement in nucleic acid processing or integration. The gene is broadly expressed in various tissues, with highest expression in the testis and brain. Its precise biological function remains under investigation, but it may play roles in RNA metabolism, DNA repair, or cellular stress responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association established | Not applicable | No curated evidence in ClinVar, OMIM, or COSMIC as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Medium |
| Lung | 5.1 | Low |
| Liver | 3.2 | Low |
| Kidney | 4.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 6.7 | Moderate expression |
| HeLa | 5.2 | Low expression |
| K562 | 4.8 | Low expression |
| HepG2 | 3.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No significant variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in curated databases.
Gain of Function (GOF)
No documented gain-of-function mutations in curated databases.
Dominant Negative (DN)
No documented dominant-negative mutations in curated databases.
View complete mutation data：
Gene Ontology (GO)
| • nucleic acid binding (GO:0003676) | • nuclease activity (GO:0004518) |
| • nucleus (GO:0005634) | • cytoplasm (GO:0005737) |
Pathways
• No curated pathway associations in Reactome or KEGG
Protein Summary
The NYNRIN protein (UniProt Q9H6U6) is 1,038 amino acids long and contains an NYN domain (residues 1-150) and a retroviral integrase-like domain (residues 400-600). The NYN domain is predicted to have nuclease activity, possibly involved in RNA processing or degradation. The integrase domain suggests potential DNA-binding or integration activity, though no specific substrates have been identified. The protein is localized to both the nucleus and cytoplasm, indicating possible multifunctional roles. Structural studies are limited, and functional characterization remains incomplete.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NYNRIN Knockout HEK293 Cell Line | EDJ-KQ14538 | Human | 57523 | Details Get a Quote |
| NYNRIN Knockout HeLa Cell Line | EDJ-KQ44821 | Human | 57523 | Details Get a Quote |
| NYNRIN Knockout A-549 Cell Line | EDJ-KQ65369 | Human | 57523 | Details Get a Quote |
| NYNRIN Knockout HCT 116 Cell Line | EDJ-KQ73807 | Human | 57523 | Details Get a Quote |
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