NUDT16
Nudix Hydrolase 16: A Key Regulator of Inosine Diphosphate and RNA Decapping
Gene Information Card
| Symbol | NUDT16 |
|---|---|
| Full Name | Nudix Hydrolase 16 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q26.31 |
| NCBI Gene ID | 131870 ncbi.nlm.nih.gov/gene/131870 |
| Ensembl ID | ENSG00000198576 |
| UniProt ID | Q96DE0 |
| OMIM ID | 609230 |
| HGNC ID | 26421 |
| Aliases | IDPase, MGC20785, FLJ20643 |
Description
NUDT16 encodes a member of the nudix hydrolase family. The protein specifically hydrolyzes inosine diphosphate (IDP) to inosine monophosphate (IMP) and inorganic phosphate, and also functions as a decapping enzyme for RNA, removing the 5' cap from small nuclear RNAs and mRNAs. It plays a role in nucleotide metabolism and RNA turnover.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression may affect nucleotide pools and RNA stability | NCBI Gene, COSMIC |
| Hepatocellular carcinoma | Upregulation observed; potential role in tumor progression | COSMIC, PubMed |
| Colorectal cancer | Differential expression reported | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Testis | 6.7 | Low |
| Brain | 4.2 | Low |
| Heart | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| HEK293 | 10.8 | Embryonic kidney cells |
| HeLa | 7.5 | Cervical cancer cells |
| A549 | 5.9 | Lung carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Unknown functional impact |
| c.454G>A (p.Gly152Ser) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; potential loss of hydrolase activity may affect nucleotide pools.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Purine metabolism (Reactome: R-HSA-74217)
• RNA degradation (Reactome: R-HSA-8953854)
Protein Summary
NUDT16 is a 184-amino acid protein (20.5 kDa) belonging to the nudix hydrolase superfamily. It contains a conserved nudix box motif (GX5EX7REUXEEXGU, where U is a hydrophobic residue). The protein exists as a monomer and requires divalent metal ions (Mg2+ or Mn2+) for activity. It catalyzes the hydrolysis of IDP to IMP and also removes the 5' cap from RNA, contributing to RNA quality control.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NUDT16 Knockout HEK293 Cell Line | EDJ-KQ9276 | Human | 131870 | Details Get a Quote |
| NUDT16 Knockout A-549 Cell Line | EDJ-KQ35885 | Human | 131870 | Details Get a Quote |
| NUDT16 Knockout HCT 116 Cell Line | EDJ-KQ35886 | Human | 131870 | Details Get a Quote |
| NUDT16 Knockout HeLa Cell Line | EDJ-KQ35887 | Human | 131870 | Details Get a Quote |
| NUDT16L1 Knockout HEK293 Cell Line | EDJ-KQ51837 | Human | 84309 | Details Get a Quote |
| NUDT16L1 Knockout HeLa Cell Line | EDJ-KQ57579 | Human | 84309 | Details Get a Quote |
| NUDT16L1 Knockout A-549 Cell Line | EDJ-KQ66075 | Human | 84309 | Details Get a Quote |
| NUDT16L1 Knockout HCT 116 Cell Line | EDJ-KQ74497 | Human | 84309 | Details Get a Quote |
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