NUDT10
Nudix Hydrolase 10
Gene Information Card
| Symbol | NUDT10 |
|---|---|
| Full Name | nudix hydrolase 10 |
| Gene Type | protein-coding |
| Chromosomal Location | Xp11.23 |
| NCBI Gene ID | 170685 ncbi.nlm.nih.gov/gene/170685 |
| Ensembl ID | ENSG00000169093 |
| UniProt ID | Q8NFP7 |
| OMIM ID | 300870 |
| HGNC ID | 26435 |
| Aliases | DIPP3, DIPP3alpha, hDIPP3alpha, APS1 |
Description
NUDT10 (nudix hydrolase 10) encodes a member of the nudix hydrolase family. The protein specifically hydrolyzes diphosphoinositol polyphosphates, such as diphosphoinositol pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8), converting them to lower inositol phosphates. This activity regulates cellular signaling, energy metabolism, and phosphate homeostasis. NUDT10 is also known as diphosphoinositol polyphosphate phosphohydrolase 3 (DIPP3).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression may affect inositol pyrophosphate signaling, influencing cell proliferation | COSMIC; PMID: 23503656 |
| Prostate cancer | Potential role in androgen receptor signaling modulation via inositol pyrophosphate metabolism | COSMIC; PMID: 23503656 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Liver | 5.1 | Low |
| Kidney | 4.7 | Low |
| Heart | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | Embryonic kidney cells |
| HeLa | 7.8 | Cervical cancer cells |
| MCF7 | 6.5 | Breast cancer cells |
| HepG2 | 4.9 | Hepatocellular carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | 0.001% (gnomAD) | Unknown functional effect |
| c.418G>A (p.Gly140Ser) | Missense | 0.002% (gnomAD) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • diphosphoinositol-polyphosphate diphosphatase activity | • inositol phosphate phosphatase activity |
| • magnesium ion binding | • hydrolase activity |
| • cytoplasm | • nucleus |
Pathways
• Inositol phosphate metabolism
• Phosphatidylinositol signaling system
Protein Summary
NUDT10 encodes a 164-amino acid protein (UniProt Q8NFP7) belonging to the nudix hydrolase family. It contains a conserved nudix box motif (GX5EX7REUXEEXGU, where U is a hydrophobic residue). The enzyme catalyzes the hydrolysis of diphosphoinositol polyphosphates, removing the beta-phosphate from the diphosphate group, thereby regulating intracellular levels of InsP7 and InsP8. The protein is localized in the cytoplasm and nucleus.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NUDT10 Knockout HEK293 Cell Line | EDJ-KQ14514 | Human | 170685 | Details Get a Quote |
| NUDT10 Knockout HeLa Cell Line | EDJ-KQ58944 | Human | 170685 | Details Get a Quote |
| NUDT10 Knockout A-549 Cell Line | EDJ-KQ67431 | Human | 170685 | Details Get a Quote |
| NUDT10 Knockout HCT 116 Cell Line | EDJ-KQ75826 | Human | 170685 | Details Get a Quote |
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