NUDCD3
NudC Domain Containing 3
Gene Information Card
| Symbol | NUDCD3 |
|---|---|
| Full Name | NudC Domain Containing 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 7p13 |
| NCBI Gene ID | 23386 ncbi.nlm.nih.gov/gene/23386 |
| Ensembl ID | ENSG00000105971 |
| UniProt ID | Q8IVD9 |
| OMIM ID | 610385 |
| HGNC ID | 22223 |
| Aliases | NUDCD3, C7orf30, NudCL3 |
Description
NUDCD3 (NudC Domain Containing 3) is a protein-coding gene that encodes a member of the NudC family of proteins. The protein is involved in cell cycle regulation, particularly in mitotic spindle organization and cytokinesis. It interacts with dynein and dynactin complexes to facilitate proper chromosome segregation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | Not applicable |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Bone marrow | 11.5 | Medium |
| Spleen | 10.9 | Medium |
| Brain | 8.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 14.1 | Leukemia cell line |
| HeLa | 12.5 | Cervical carcinoma |
| HEK 293 | 11.0 | Embryonic kidney |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Gene Ontology (GO)
| • cell division | • mitotic spindle organization |
| • cytokinesis | • protein binding |
| • dynein complex binding |
Pathways
• Cell Cycle
• Mitotic
• Resolution of Sister Chromatid Cohesion
Protein Summary
The NUDCD3 protein is 546 amino acids long and contains a NudC domain. It localizes to the centrosome and spindle poles during mitosis, where it regulates dynein-mediated transport and ensures accurate chromosome segregation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| No Data | ||||
