NTSR2
Neurotensin Receptor 2
Gene Information Card
| Symbol | NTSR2 |
|---|---|
| Full Name | Neurotensin Receptor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 2p25.1 |
| NCBI Gene ID | 23620 ncbi.nlm.nih.gov/gene/23620 |
| Ensembl ID | ENSG00000169006 |
| UniProt ID | O95665 |
| OMIM ID | 602642 |
| HGNC ID | 8040 |
| Aliases | NT2R, NTR2 |
Description
NTSR2 (Neurotensin Receptor 2) encodes a G protein-coupled receptor for neurotensin, a neuropeptide involved in pain modulation, dopamine signaling, and thermoregulation. The receptor is primarily expressed in the brain and peripheral tissues, mediating cellular responses via phospholipase C activation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Schizophrenia | Altered neurotensin signaling; NTSR2 variants may affect dopamine pathways | PMID: 10807545 |
| Substance Use Disorders | Modulation of reward circuitry via NTSR2 | PMID: 15615661 |
| Pain Disorders | NTSR2 mediates analgesic effects of neurotensin | PMID: 12052191 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebellum) | 5.2 | Medium |
| Brain (hippocampus) | 4.8 | Medium |
| Adipose tissue | 1.1 | Low |
| Heart | 0.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 3.5 | Neuroblastoma cell line |
| HEK293 | 0.2 | Low expression |
| U-87 MG | 1.8 | Glioblastoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Reduced receptor activity in vitro |
| c.452G>A (p.Arg151His) | Missense | <0.01% | Altered ligand binding |
Mutation functional classification
Loss of Function (LOF)
p.Thr34Met reduces receptor signaling
Gain of Function (GOF)
None reported
Dominant Negative (DN)
None reported
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • neurotensin receptor activity |
| • phospholipase C-activating G protein-coupled receptor signaling pathway | • plasma membrane |
Pathways
• Neurotensin signaling pathway
• GPCR downstream signaling
Protein Summary
Neurotensin receptor 2 (NTSR2) is a 416-amino acid transmembrane protein belonging to the class A GPCR family. It binds neurotensin with high affinity and activates Gq/11 proteins, leading to intracellular calcium mobilization. NTSR2 is implicated in pain modulation, psychiatric disorders, and metabolic regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NTSR2 Knockout HEK293 Cell Line | EDJ-KQ7426 | Human | 23620 | Details Get a Quote |
| NTSR2 Knockout HeLa Cell Line | EDJ-KQ55784 | Human | 23620 | Details Get a Quote |
| NTSR2 Knockout A-549 Cell Line | EDJ-KQ64279 | Human | 23620 | Details Get a Quote |
| NTSR2 Knockout HCT 116 Cell Line | EDJ-KQ72725 | Human | 23620 | Details Get a Quote |
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