NTN5 Gene - Netrin 5
Comprehensive gene card for NTN5 (Netrin 5) including genomic annotation, expression, and disease associations.
Gene Information Card
| Symbol | NTN5 |
|---|---|
| Full Name | Netrin 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 126147 ncbi.nlm.nih.gov/gene/126147 |
| Ensembl ID | ENSG00000186111 |
| UniProt ID | Q8N8Z6 |
| OMIM ID | 617814 |
| HGNC ID | 13687 |
| Aliases | NETRIN-5, NTN5L |
Description
NTN5 (Netrin 5) is a protein-coding gene belonging to the netrin family of secreted proteins involved in axon guidance and cell migration. The encoded protein contains a laminin-like domain and is implicated in neural development and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations currently curated in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 2.3 | Low |
| Testis | 1.1 | Low |
| Kidney | 0.8 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 1.5 | Low expression |
| HEK293 (embryonic kidney) | 0.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • chemorepellent activity (GO:0008009) |
| • axon guidance (GO:0007411) |
Pathways
• Netrin signaling (Reactome: R-HSA-373752)
Protein Summary
Netrin 5 is a secreted protein that belongs to the netrin family. It contains a laminin N-terminal domain and three EGF-like repeats. The protein is involved in axon guidance and may play a role in cell migration during development. Expression is low in most adult tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NTN5 Knockout HEK293 Cell Line | EDJ-KQ8863 | Human | 126147 | Details Get a Quote |
| NTN5 Knockout HeLa Cell Line | EDJ-KQ58167 | Human | 126147 | Details Get a Quote |
| NTN5 Knockout A-549 Cell Line | EDJ-KQ66655 | Human | 126147 | Details Get a Quote |
| NTN5 Knockout HCT 116 Cell Line | EDJ-KQ75073 | Human | 126147 | Details Get a Quote |
