NTN4 (Netrin 4) Gene
A comprehensive guide to the NTN4 gene, its function, expression, and associated diseases.
Gene Information Card
| Symbol | NTN4 |
|---|---|
| Full Name | Netrin 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 12q22 |
| NCBI Gene ID | 59277 ncbi.nlm.nih.gov/gene/59277 |
| Ensembl ID | ENSG00000111011 |
| UniProt ID | Q9HB63 |
| OMIM ID | 607884 |
| HGNC ID | 13658 |
| Aliases | NET4, netrin-4, beta-netrin |
Description
NTN4 (Netrin 4) is a protein-coding gene that encodes a member of the netrin family of secreted proteins. Netrins are involved in axon guidance, cell migration, and angiogenesis. NTN4 is expressed in various tissues and plays roles in neural development, vascular patterning, and tumor suppression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | NTN4 may act as a tumor suppressor; reduced expression is associated with poor prognosis. | PMID: 22952446 |
| Diabetic Nephropathy | NTN4 expression is altered in diabetic kidney disease, affecting podocyte survival and matrix remodeling. | PMID: 25934867 |
| Schizophrenia | Genetic variants in NTN4 have been associated with schizophrenia risk in some populations. | PMID: 21743477 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Brain | 8.3 | Medium |
| Lung | 6.1 | Low |
| Heart | 4.2 | Low |
| Liver | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | Embryonic kidney cells |
| SH-SY5Y | 9.8 | Neuroblastoma cells |
| MCF7 | 3.5 | Breast cancer cells |
| HepG2 | 1.2 | Hepatocellular carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | 0.01% | Unknown functional impact |
| c.457G>A (p.Val153Ile) | Missense | 0.02% | Reported in breast cancer |
| c.1234delC | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.1234delC) are predicted to cause loss of function, potentially contributing to tumor progression.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • axon guidance | • cell adhesion |
| • angiogenesis | • extracellular matrix organization |
| • netrin receptor binding |
Pathways
• Netrin signaling
• Axon guidance
• Integrin signaling
Protein Summary
Netrin-4 is a secreted protein of approximately 70 kDa. It contains a laminin N-terminal domain, three EGF-like repeats, and a C-terminal netrin domain. It binds to integrins and neogenin receptors, regulating cell migration and adhesion. Netrin-4 is involved in neural development, blood vessel formation, and tumor suppression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NTN4 Knockout HEK293 Cell Line | EDJ-KQ14510 | Human | 59277 | Details Get a Quote |
| NTN4 Knockout A-549 Cell Line | EDJ-KQ44782 | Human | 59277 | Details Get a Quote |
| NTN4 Knockout HCT 116 Cell Line | EDJ-KQ44783 | Human | 59277 | Details Get a Quote |
| NTN4 Knockout HeLa Cell Line | EDJ-KQ43531 | Human | 59277 | Details Get a Quote |
