NTN3 (Netrin 3)
Axon guidance molecule involved in neural development and cancer
Gene Information Card
| Symbol | NTN3 |
|---|---|
| Full Name | Netrin 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 4917 ncbi.nlm.nih.gov/gene/4917 |
| Ensembl ID | ENSG00000162032 |
| UniProt ID | O00634 |
| OMIM ID | 603114 |
| HGNC ID | 8010 |
| Aliases | NET3, netrin-3 |
Description
NTN3 encodes netrin 3, a member of the netrin family of secreted proteins that function as axon guidance cues during neural development. Netrin 3 binds to DCC and UNC5 receptors to mediate chemoattraction and chemorepulsion. It is also implicated in tumorigenesis and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered expression may promote tumor progression via netrin signaling | PMID: 19029980 |
| Breast cancer | Netrin 3 overexpression associated with poor prognosis | PMID: 25652263 |
| Neural tube defects | Potential role in developmental anomalies | OMIM: 603114 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 2.1 | Low |
| Spinal cord | 1.8 | Low |
| Testis | 0.5 | Not detected |
| Heart | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 1.5 | Low expression |
| MCF7 (breast cancer) | 0.8 | Not detected |
| HeLa (cervical cancer) | 0.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.1% | Unknown functional impact |
| c.205G>A (p.Gly69Ser) | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • axon guidance (GO:0007411) | • growth factor activity (GO:0008083) |
| • extracellular region (GO:0005576) | • signal transduction (GO:0007165) |
Pathways
• Netrin signaling (Reactome: R-HSA-373752)
• Axon guidance (KEGG: hsa04360)
Protein Summary
Netrin 3 is a secreted protein of 580 amino acids (UniProt O00634) containing a laminin N-terminal domain and a netrin C-terminal domain. It functions as a bifunctional axon guidance cue, attracting or repelling growth cones via DCC and UNC5 receptors. Expression is primarily in neural tissues during development.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NTN3 Knockout HEK293 Cell Line | EDJ-KQ50490 | Human | 4917 | Details Get a Quote |
| NTN3 Knockout HeLa Cell Line | EDJ-KQ54032 | Human | 4917 | Details Get a Quote |
| NTN3 Knockout A-549 Cell Line | EDJ-KQ62519 | Human | 4917 | Details Get a Quote |
| NTN3 Knockout HCT 116 Cell Line | EDJ-KQ70992 | Human | 4917 | Details Get a Quote |
