NRK (Nik Related Kinase)
Gene encoding a serine/threonine kinase involved in cell cycle regulation and tumor suppression
Gene Information Card
| Symbol | NRK |
|---|---|
| Full Name | Nik Related Kinase |
| Gene Type | Protein coding |
| Chromosomal Location | Xq22.3 |
| NCBI Gene ID | 203447 ncbi.nlm.nih.gov/gene/203447 |
| Ensembl ID | ENSG00000169031 |
| UniProt ID | Q7Z2Y5 |
| OMIM ID | 300791 |
| HGNC ID | 29538 |
| Aliases | NIK-like kinase, Nlk |
Description
NRK (Nik Related Kinase) encodes a serine/threonine kinase belonging to the NIK (Never in Mitosis A-related kinase) family. The protein is involved in cell cycle regulation, particularly in mitotic progression and cytokinesis. NRK has been implicated in tumor suppression through its role in maintaining genomic stability. Mutations and altered expression of NRK are associated with various cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression and mutations in NRK may disrupt cell cycle control, contributing to tumorigenesis | COSMIC, ClinVar |
| Colorectal cancer | Loss of NRK function leads to genomic instability and aneuploidy | COSMIC, PubMed |
| Primary microcephaly | Mutations in NRK impair mitotic spindle organization, reducing neuronal progenitor cell proliferation | OMIM, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.3 | Low |
| Brain | 6.1 | Low |
| Lung | 4.7 | Low |
| Liver | 3.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| K562 | 10.8 | Leukemia cell line |
| MCF7 | 9.4 | Breast cancer cell line |
| HepG2 | 5.6 | Liver cancer cell line |
| A549 | 4.1 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function; truncation of kinase domain |
| c.567G>A (p.Trp189*) | Nonsense | <0.1% | Loss of function; premature stop codon |
| c.890A>G (p.Tyr297Cys) | Missense | <0.1% | Unknown; may affect kinase activity |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg412*, p.Trp189*) result in truncated, non-functional protein, leading to loss of kinase activity and impaired cell cycle regulation.
Gain of Function (GOF)
No gain-of-function mutations have been reported for NRK in curated databases.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for NRK.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004672 (GO:0004672) | • GO:0005524 (GO:0005524) |
| • GO:0007049 (GO:0007049) | • GO:0051301 (GO:0051301) |
| • GO:0005819 (GO:0005819) |
Pathways
• Cell cycle (KEGG hsa04110)
• Mitotic spindle organization (Reactome R-HSA-68877)
Protein Summary
NRK encodes a 1,258-amino acid serine/threonine kinase with an N-terminal kinase domain and a C-terminal regulatory region. The protein localizes to the centrosome and spindle poles during mitosis, where it regulates microtubule dynamics and cytokinesis. NRK interacts with components of the mitotic checkpoint complex, ensuring proper chromosome segregation. Loss of NRK function leads to mitotic errors, aneuploidy, and genomic instability, linking it to tumor suppression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NRK Knockout HEK293 Cell Line | EDJ-KQ5534 | Human | 203447 | Details Get a Quote |
| SNRK Knockout HEK293 Cell Line | EDJ-KQ15407 | Human | 54861 | Details Get a Quote |
| SNRK Knockout A-549 Cell Line | EDJ-KQ46179 | Human | 54861 | Details Get a Quote |
| SNRK Knockout HCT 116 Cell Line | EDJ-KQ46180 | Human | 54861 | Details Get a Quote |
| SNRK Knockout HeLa Cell Line | EDJ-KQ46181 | Human | 54861 | Details Get a Quote |
| NRK Knockout HeLa Cell Line | EDJ-KQ59046 | Human | 203447 | Details Get a Quote |
| NRK Knockout A-549 Cell Line | EDJ-KQ67524 | Human | 203447 | Details Get a Quote |
| NRK Knockout HCT 116 Cell Line | EDJ-KQ75921 | Human | 203447 | Details Get a Quote |
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