NRIP3 (Nuclear Receptor Interacting Protein 3)
A gene encoding a nuclear receptor cofactor with potential roles in transcriptional regulation and cancer biology.
Gene Information Card
| Symbol | NRIP3 |
|---|---|
| Full Name | Nuclear Receptor Interacting Protein 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.5 |
| NCBI Gene ID | 56675 ncbi.nlm.nih.gov/gene/56675 |
| Ensembl ID | ENSG00000148773 |
| UniProt ID | Q9NQ35 |
| OMIM ID | 617993 |
| HGNC ID | 24901 |
| Aliases | C11orf14, FLJ11127, MGC138290 |
Description
NRIP3 (nuclear receptor interacting protein 3) encodes a protein that interacts with nuclear receptors and may function as a transcriptional cofactor. The gene is located on chromosome 11p15.5 and is expressed in multiple tissues. Its exact biological roles are still under investigation, but it has been implicated in cellular signaling and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Potential involvement in estrogen receptor signaling; altered expression observed in tumor samples. | COSMIC, literature |
| Colorectal cancer | Differential expression and somatic mutations reported in colorectal tumors. | COSMIC, literature |
| Lung cancer | Somatic mutations and expression changes noted in lung adenocarcinoma. | COSMIC, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.2 | Medium |
| Thyroid | 6.5 | Medium |
| Prostate | 5.1 | Medium |
| Breast | 4.3 | Low |
| Colon | 3.8 | Low |
| Lung | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 6.0 | Embryonic kidney cell line |
| MCF7 | 4.5 | Breast cancer cell line |
| A549 | 3.2 | Lung cancer cell line |
| HCT116 | 3.0 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287G>A (p.Arg96His) | Missense | <0.1% | Unknown functional impact |
| c.412C>T (p.Pro138Ser) | Missense | <0.1% | Unknown functional impact |
| c.523_524insA | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.523_524insA) are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been described.
View complete mutation data：
Gene Ontology (GO)
| • nuclear receptor binding | • transcription coactivator activity |
| • nucleus | • cytoplasm |
| • protein binding |
Pathways
• Nuclear receptor signaling
• Transcriptional regulation
Protein Summary
The NRIP3 protein is a 305-amino-acid nuclear receptor interacting protein. It contains a nuclear localization signal and is predicted to localize to the nucleus and cytoplasm. Its exact molecular function is not fully characterized, but it is thought to modulate nuclear receptor-mediated transcription.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NRIP3 Knockout HEK293 Cell Line | EDJ-KQ14497 | Human | 56675 | Details Get a Quote |
| NRIP3 Knockout A-549 Cell Line | EDJ-KQ44763 | Human | 56675 | Details Get a Quote |
| NRIP3 Knockout HeLa Cell Line | EDJ-KQ44764 | Human | 56675 | Details Get a Quote |
| NRIP3 Knockout HCT 116 Cell Line | EDJ-KQ73694 | Human | 56675 | Details Get a Quote |
