NRIP2: Nuclear Receptor Interacting Protein 2
A coregulator of nuclear receptor signaling with roles in transcriptional regulation and potential implications in cancer and metabolic disorders.
Gene Information Card
| Symbol | NRIP2 |
|---|---|
| Full Name | Nuclear Receptor Interacting Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 12q21.1 |
| NCBI Gene ID | 83714 ncbi.nlm.nih.gov/gene/83714 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | Q9Y4P3 |
| OMIM ID | 606164 |
| HGNC ID | 18019 |
| Aliases | FLJ20156, MGC138290, MGC138291 |
Description
NRIP2 (Nuclear Receptor Interacting Protein 2) encodes a protein that functions as a transcriptional coregulator, interacting with nuclear receptors such as estrogen receptor alpha (ERα) and retinoid X receptor (RXR). It modulates gene expression by recruiting coactivator or corepressor complexes, influencing processes like cell proliferation, differentiation, and metabolism. NRIP2 is expressed in multiple tissues and has been implicated in breast cancer and other malignancies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | NRIP2 may modulate ERα signaling, affecting tumor growth and hormone sensitivity. | PMID: 15601843 |
| Prostate Cancer | Potential role in androgen receptor signaling regulation. | PMID: 17690110 |
| Metabolic Syndrome | Involvement in lipid and glucose metabolism via nuclear receptor interactions. | PMID: 19074966 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Liver | 8.3 | Low |
| Kidney | 15.2 | Medium |
| Breast | 20.1 | High |
| Prostate | 18.7 | High |
| Testis | 22.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 25.3 | ER-positive cell line |
| LNCaP (prostate cancer) | 19.8 | Androgen-sensitive |
| HepG2 (liver cancer) | 9.1 | Low expression |
| HEK293 (embryonic kidney) | 14.6 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Pro34Leu) | Missense | <0.01% | Unknown functional impact |
| c.452G>A (p.Arg151Gln) | Missense | <0.01% | Reported in COSMIC; potential loss of interaction |
| c.789_790insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations likely lead to truncated protein and loss of coregulator activity.
Gain of Function (GOF)
Not well documented; some missense variants may alter interaction affinity.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Nuclear receptor signaling pathway
• Estrogen signaling pathway
• Retinoid X receptor (RXR) pathway
Protein Summary
The NRIP2 protein is a 572-amino acid nuclear protein that contains a nuclear receptor interaction domain (NR box) and a glutamine-rich region. It acts as a scaffold for transcriptional complexes, modulating the activity of nuclear receptors. Its expression is highest in testis, breast, and prostate tissues, and it is implicated in hormone-dependent cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NRIP2 Knockout HEK293 Cell Line | EDJ-KQ9894 | Human | 83714 | Details Get a Quote |
| NRIP2 Knockout HCT 116 Cell Line | EDJ-KQ35576 | Human | 83714 | Details Get a Quote |
| NRIP2 Knockout HeLa Cell Line | EDJ-KQ36775 | Human | 83714 | Details Get a Quote |
| NRIP2 Knockout A-549 Cell Line | EDJ-KQ65974 | Human | 83714 | Details Get a Quote |
