NPY5R
Neuropeptide Y Receptor Y5
Gene Information Card
| Symbol | NPY5R |
|---|---|
| Full Name | Neuropeptide Y Receptor Y5 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q31.3 |
| NCBI Gene ID | 4889 ncbi.nlm.nih.gov/gene/4889 |
| Ensembl ID | ENSG00000164129 |
| UniProt ID | Q15761 |
| OMIM ID | 602001 |
| HGNC ID | 7958 |
| Aliases | NPY5-R, NPYY5-R, Y5 receptor |
Description
NPY5R encodes a G protein-coupled receptor for neuropeptide Y (NPY) and peptide YY (PYY). The receptor is primarily expressed in the central nervous system and plays a key role in appetite regulation, energy homeostasis, and anxiety. It mediates NPY-induced feeding behavior and is a target for anti-obesity drug development.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | NPY5R activation increases food intake; variants may alter receptor sensitivity | ClinVar, OMIM |
| Anxiety disorders | NPY signaling via NPY5R modulates stress and anxiety responses | OMIM, PubMed |
| Metabolic syndrome | Dysregulation of NPY5R contributes to insulin resistance and adiposity | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Medium |
| Hypothalamus | 8.1 | High |
| Adipose tissue | 1.3 | Low |
| Kidney | 0.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 3.4 | Neuroblastoma cell line |
| HEK293 | 0.2 | Low endogenous expression |
| SK-N-BE(2) | 2.1 | Neuroblastoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Val38Ile) | missense | <0.01% | Unknown; rare variant |
| c.661C>T (p.Arg221Cys) | missense | <0.01% | Potential loss of function |
| c.1025A>G (p.Asn342Ser) | missense | <0.01% | Altered ligand binding |
Mutation functional classification
Loss of Function (LOF)
p.Arg221Cys may impair receptor signaling
Gain of Function (GOF)
No confirmed gain-of-function variants reported
Dominant Negative (DN)
Not described
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • neuropeptide Y receptor activity |
| • peptide YY receptor activity | • plasma membrane |
| • signal transduction | • feeding behavior |
| • positive regulation of appetite |
Pathways
• Neuropeptide Y signaling pathway
• GPCR downstream signaling
• Regulation of appetite and energy homeostasis
Protein Summary
NPY5R is a 445-amino acid integral membrane protein with seven transmembrane domains. It couples to Gi/o proteins, inhibiting adenylyl cyclase and modulating intracellular calcium. The receptor is a key mediator of NPY's orexigenic effects and is expressed in hypothalamic nuclei involved in energy balance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NPY5R Knockout HEK293 Cell Line | EDJ-KQ5359 | Human | 4889 | Details Get a Quote |
| NPY5R Knockout HeLa Cell Line | EDJ-KQ54021 | Human | 4889 | Details Get a Quote |
| NPY5R Knockout A-549 Cell Line | EDJ-KQ62511 | Human | 4889 | Details Get a Quote |
| NPY5R Knockout HCT 116 Cell Line | EDJ-KQ70982 | Human | 4889 | Details Get a Quote |
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