NPY4R2 (Neuropeptide Y Receptor Y4-2): A Pseudogene-Derived GPCR with Potential Roles in Neuroendocrine Signaling
Explore the genomic context, expression patterns, and functional annotations of NPY4R2, a neuropeptide Y receptor family member with limited protein-coding evidence.
Gene Information Card
| Symbol | NPY4R2 |
|---|---|
| Full Name | Neuropeptide Y Receptor Y4-2 |
| Gene Type | protein-coding (with pseudogene characteristics) |
| Chromosomal Location | 10q11.22 |
| NCBI Gene ID | 646028 ncbi.nlm.nih.gov/gene/646028 |
| Ensembl ID | ENSG00000204176 |
| UniProt ID | Q5J5Y7 |
| OMIM ID | Not assigned |
| HGNC ID | HGNC:4529 |
| Aliases | NPY4R2, PPYR2, Y4-2 |
Description
NPY4R2 (Neuropeptide Y Receptor Y4-2) is a gene located on chromosome 10q11.22, encoding a putative G-protein coupled receptor related to the neuropeptide Y receptor family. Although annotated as protein-coding, NPY4R2 exhibits characteristics of a pseudogene, including a truncated open reading frame and lack of canonical introns. It is expressed at low levels in certain tissues, but its functional significance remains unclear. The gene is part of a cluster of neuropeptide Y receptor genes and may have arisen from a duplication event. No disease associations have been established to date.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations reported | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.4 | Low |
| Brain | 0.1 | Low |
| Other tissues | Not detected | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line data available | Not applicable | No expression data in cell lines from Human Protein Atlas |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No clinically significant variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No evidence of loss-of-function mutations in NPY4R2; gene is likely non-functional due to pseudogene characteristics.
Gain of Function (GOF)
No evidence of gain-of-function mutations; gene is not expressed at significant levels.
Dominant Negative (DN)
No evidence of dominant-negative effects; gene is not implicated in any disease.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • neuropeptide Y receptor activity |
| • plasma membrane | • signal transduction |
Pathways
• Neuropeptide Y signaling pathway (inferred from family membership)
• GPCR downstream signaling
Protein Summary
The NPY4R2 protein is predicted to be a seven-transmembrane G-protein coupled receptor, but due to a truncated reading frame, it is unlikely to produce a functional receptor. The protein sequence shows similarity to the neuropeptide Y receptor Y4, but lacks key residues required for ligand binding. No experimental evidence of protein expression exists.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NPY4R2 Knockout HEK293 Cell Line | EDJ-KQ11891 | Human | 100996758 | Details Get a Quote |
| NPY4R2 Knockout A-549 Cell Line | EDJ-KQ40344 | Human | 100996758 | Details Get a Quote |
| NPY4R2 Knockout HeLa Cell Line | EDJ-KQ40345 | Human | 100996758 | Details Get a Quote |
| NPY4R2 Knockout HCT 116 Cell Line | EDJ-KQ77813 | Human | 100996758 | Details Get a Quote |
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