NPY2R
Neuropeptide Y Receptor Y2
Gene Information Card
| Symbol | NPY2R |
|---|---|
| Full Name | Neuropeptide Y Receptor Y2 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q31.1 |
| NCBI Gene ID | 4887 ncbi.nlm.nih.gov/gene/4887 |
| Ensembl ID | ENSG00000185149 |
| UniProt ID | P49146 |
| OMIM ID | 162642 |
| HGNC ID | 7958 |
| Aliases | NPY2-R, Y2 receptor |
Description
The NPY2R gene encodes the neuropeptide Y receptor Y2, a G protein-coupled receptor that binds neuropeptide Y (NPY) and peptide YY (PYY). It is involved in the regulation of food intake, energy homeostasis, anxiety, and vasoconstriction. The receptor is predominantly expressed in the central nervous system and peripheral tissues, mediating inhibitory effects on neurotransmitter release and appetite.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | NPY2R variants may alter receptor signaling affecting appetite regulation and energy balance. | ClinVar, OMIM |
| Anxiety Disorders | NPY2R polymorphisms are associated with altered stress response and anxiety-like behaviors. | NCBI Gene, OMIM |
| Hypertension | NPY2R-mediated vasoconstriction contributes to blood pressure regulation; variants may influence hypertension risk. | UniProt, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cortex) | 8.5 | Medium |
| Brain (hippocampus) | 6.2 | Medium |
| Adipose tissue | 3.1 | Low |
| Colon | 2.8 | Low |
| Heart | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 4.3 | Neuroblastoma cell line |
| HEK293 | 2.1 | Embryonic kidney cells |
| HepG2 | 1.8 | Hepatocellular carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | <0.01% | Altered ligand binding affinity (ClinVar) |
| c.425C>T (p.Thr142Met) | Missense | <0.01% | Reduced receptor expression (ClinVar) |
| c.788A>G (p.Asn263Ser) | Missense | <0.01% | Impaired G protein coupling (COSMIC) |
Mutation functional classification
Loss of Function (LOF)
p.Gly38Arg and p.Thr142Met reduce receptor activity and expression.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • neuropeptide Y receptor activity |
| • peptide YY receptor activity | • plasma membrane |
| • signal transduction | • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
Pathways
• Neuropeptide Y signaling pathway
• GPCR downstream signaling
• Regulation of appetite
Protein Summary
The NPY2R protein is a 381-amino acid G protein-coupled receptor with seven transmembrane domains. It is activated by NPY and PYY, leading to inhibition of adenylate cyclase and modulation of intracellular calcium levels. The receptor plays a key role in appetite suppression, anxiety reduction, and vascular tone regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NPY2R Knockout HEK293 Cell Line | EDJ-KQ4580 | Human | 4887 | Details Get a Quote |
| NPY2R Knockout HeLa Cell Line | EDJ-KQ54020 | Human | 4887 | Details Get a Quote |
| NPY2R Knockout A-549 Cell Line | EDJ-KQ62510 | Human | 4887 | Details Get a Quote |
| NPY2R Knockout HCT 116 Cell Line | EDJ-KQ70981 | Human | 4887 | Details Get a Quote |
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