NPBWR1: Neuropeptides B/W Receptor 1
G protein-coupled receptor for neuropeptide B and W, involved in energy homeostasis and neuroendocrine signaling.
Gene Information Card
| Symbol | NPBWR1 |
|---|---|
| Full Name | Neuropeptides B/W Receptor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 8q11.23 |
| NCBI Gene ID | 2831 ncbi.nlm.nih.gov/gene/2831 |
| Ensembl ID | ENSG00000104419 |
| UniProt ID | P48145 |
| OMIM ID | 600730 |
| HGNC ID | 4529 |
| Aliases | GPR7, NPBW1 |
Description
NPBWR1 encodes a G protein-coupled receptor (GPCR) that binds neuropeptide B (NPB) and neuropeptide W (NPW). It is primarily expressed in the central nervous system and plays a role in energy homeostasis, feeding behavior, pain modulation, and neuroendocrine regulation. The receptor signals through G_i/o proteins, inhibiting adenylate cyclase and modulating intracellular calcium levels.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | Altered NPBWR1 signaling may disrupt energy balance and appetite regulation, contributing to obesity. | OMIM #600730; association studies in human cohorts. |
| Neuroendocrine tumors | Aberrant expression of NPBWR1 has been observed in certain pituitary and adrenal tumors, suggesting a role in tumorigenesis. | COSMIC; limited case reports. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebral cortex) | 2.3 | Low |
| Hypothalamus | 4.1 | Medium |
| Pituitary gland | 3.8 | Medium |
| Adrenal gland | 1.5 | Low |
| Testis | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 1.8 | Low expression |
| HEK293 (embryonic kidney) | 0.2 | Not detected |
| HeLa (cervical carcinoma) | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200C>T (p.Pro67Leu) | Missense | <0.01% | Unknown functional impact; rare population variant. |
| c.487G>A (p.Val163Met) | Missense | <0.01% | Predicted benign; no known disease association. |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in NPBWR1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • neuropeptide binding |
| • neuropeptide Y receptor activity | • plasma membrane |
| • signal transduction | • G protein-coupled receptor signaling pathway |
| • feeding behavior | • energy homeostasis |
Pathways
• Neuropeptide signaling (Reactome: R-HSA-375276)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
NPBWR1 is a 7-transmembrane GPCR of the rhodopsin family. It is activated by endogenous neuropeptides B and W, leading to inhibition of cAMP production via G_i/o proteins. The receptor is highly expressed in the hypothalamus and pituitary, where it modulates appetite, stress response, and pain perception. Structural studies indicate conserved motifs for ligand binding and G protein coupling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NPBWR1 Knockout HEK293 Cell Line | EDJ-KQ4757 | Human | 2831 | Details Get a Quote |
| NPBWR1 Knockout HeLa Cell Line | EDJ-KQ53386 | Human | 2831 | Details Get a Quote |
| NPBWR1 Knockout A-549 Cell Line | EDJ-KQ61864 | Human | 2831 | Details Get a Quote |
| NPBWR1 Knockout HCT 116 Cell Line | EDJ-KQ70346 | Human | 2831 | Details Get a Quote |
