NOXRED1
NADPH-dependent oxidoreductase domain containing 1
Gene Information Card
| Symbol | NOXRED1 |
|---|---|
| Full Name | NADPH-dependent oxidoreductase domain containing 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 14q24.3 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q8N4N8 |
| OMIM ID | 617227 |
| HGNC ID | 26119 |
| Aliases | FLJ22662, MGC138290 |
Description
NOXRED1 encodes a NADPH-dependent oxidoreductase domain-containing protein. The protein is predicted to be involved in redox reactions, potentially acting as an electron transferase. Its exact biological function remains under investigation, but it is expressed in various tissues and may play a role in cellular metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association confirmed | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Heart | 6.1 | Low |
| Brain | 4.7 | Low |
| Lung | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Hepatocellular carcinoma cell line |
| HEK293 | 9.8 | Embryonic kidney cells |
| A549 | 5.4 | Lung carcinoma cells |
| K562 | 2.1 | Leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional effect |
| c.250G>A (p.Gly84Ser) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No confirmed dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
| • oxidoreductase activity | • NADPH binding |
| • electron transfer activity |
Pathways
• Metabolic pathways
• NADPH regeneration
Protein Summary
NOXRED1 is a 347-amino acid protein containing a NADPH-dependent oxidoreductase domain. It is predicted to localize to the cytoplasm and may participate in redox homeostasis. Structural analysis suggests a flavin mononucleotide (FMN) binding site, indicating potential involvement in electron transfer reactions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NOXRED1 Knockout HEK293 Cell Line | EDJ-KQ8166 | Human | 122945 | Details Get a Quote |
| NOXRED1 Knockout HeLa Cell Line | EDJ-KQ58111 | Human | 122945 | Details Get a Quote |
| NOXRED1 Knockout A-549 Cell Line | EDJ-KQ66599 | Human | 122945 | Details Get a Quote |
| NOXRED1 Knockout HCT 116 Cell Line | EDJ-KQ75015 | Human | 122945 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
