NOL3 (Nucleolar Protein 3) Gene
Apoptosis Regulator and Cancer-Associated Gene
Gene Information Card
| Symbol | NOL3 |
|---|---|
| Full Name | Nucleolar Protein 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 16q22.1 |
| NCBI Gene ID | 8996 ncbi.nlm.nih.gov/gene/8996 |
| Ensembl ID | ENSG00000140937 |
| UniProt ID | O60936 |
| OMIM ID | 605235 |
| HGNC ID | 7867 |
| Aliases | ARC, MYP, NOP30, NOL3A |
Description
NOL3 (nucleolar protein 3) encodes an anti-apoptotic protein that inhibits caspase activation and modulates cell death pathways. It is involved in cardiac and skeletal muscle protection and is dysregulated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Overexpression inhibits apoptosis, promoting tumor survival | PMID: 14562041 |
| Myocardial infarction | Protective role against ischemia-induced apoptosis | PMID: 12538875 |
| Huntington disease | Upregulation may counteract neuronal apoptosis | PMID: 17099713 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Skeletal muscle | 8.3 | Medium |
| Brain | 3.1 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 5.4 | Moderate expression |
| HEK293 | 3.8 | Low expression |
| MCF7 | 7.2 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.214C>T | Nonsense | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to truncated protein and loss of anti-apoptotic activity.
Gain of Function (GOF)
Not well characterized; overexpression in cancer may act as gain of function.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • apoptotic process | • negative regulation of apoptotic process |
| • cysteine-type endopeptidase inhibitor activity | • nucleolus |
| • cytoplasm |
Pathways
• Apoptosis
• p53 signaling pathway
Protein Summary
The NOL3 protein (ARC) is a 224-amino acid protein that inhibits apoptosis by binding to and inhibiting caspases (CASP2, CASP8) and by modulating mitochondrial cytochrome c release. It is predominantly expressed in heart and skeletal muscle.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NOL3 Knockout HEK293 Cell Line | EDJ-KQ50838 | Human | 8996 | Details Get a Quote |
| NOL3 Knockout HeLa Cell Line | EDJ-KQ55052 | Human | 8996 | Details Get a Quote |
| NOL3 Knockout A-549 Cell Line | EDJ-KQ63535 | Human | 8996 | Details Get a Quote |
| NOL3 Knockout HCT 116 Cell Line | EDJ-KQ72004 | Human | 8996 | Details Get a Quote |
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