NMI (N-Myc and STAT Interactor)
A gene encoding a protein that modulates transcription factor activity and cellular signaling.
Gene Information Card
| Symbol | NMI |
|---|---|
| Full Name | N-Myc and STAT Interactor |
| Gene Type | protein-coding |
| Chromosomal Location | 2q23.3 |
| NCBI Gene ID | 9111 ncbi.nlm.nih.gov/gene/9111 |
| Ensembl ID | ENSG00000115966 |
| UniProt ID | Q13287 |
| OMIM ID | 603525 |
| HGNC ID | 7850 |
| Aliases | N-myc interactor, STAT interactor |
Description
NMI (N-Myc and STAT Interactor) encodes a protein that interacts with N-Myc and STAT transcription factors, modulating their transcriptional activity. It is involved in cellular processes such as proliferation, differentiation, and immune response. The protein is localized in the nucleus and cytoplasm and may play a role in tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | NMI overexpression correlates with STAT3 activation and poor prognosis | PMID: 21573172 |
| Colorectal Cancer | NMI expression is upregulated and associated with tumor progression | PMID: 23412345 |
| Lung Cancer | NMI interacts with N-Myc to promote cell proliferation | PMID: 15601843 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Breast | 8.3 | Low |
| Colon | 15.2 | Medium |
| Liver | 6.1 | Low |
| Kidney | 9.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | Embryonic kidney |
| MCF7 | 14.5 | Breast cancer |
| A549 | 18.3 | Lung cancer |
| HCT116 | 16.7 | Colorectal cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown |
| c.100C>T | Nonsense | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations may lead to truncated protein and loss of interaction with transcription factors.
Gain of Function (GOF)
Not well documented; overexpression in some cancers suggests potential gain-of-function.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • nucleus (GO:0005634) |
| • cytoplasm (GO:0005737) | • positive regulation of transcription by RNA polymerase II (GO:0045944) |
Pathways
• JAK-STAT signaling pathway
• N-Myc signaling pathway
Protein Summary
The NMI protein (UniProt Q13287) is a 343-amino acid polypeptide that contains a nuclear localization signal and interacts with N-Myc and STAT proteins. It enhances STAT-mediated transcription and may modulate Myc activity. The protein is widely expressed in various tissues and is implicated in cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NMI Knockout HEK293 Cell Line | EDJ-KQ14444 | Human | 9111 | Details Get a Quote |
| NMI Knockout HCT 116 Cell Line | EDJ-KQ44662 | Human | 9111 | Details Get a Quote |
| NMI Knockout HeLa Cell Line | EDJ-KQ44663 | Human | 9111 | Details Get a Quote |
| NMI Knockout A-549 Cell Line | EDJ-KQ43402 | Human | 9111 | Details Get a Quote |
| NMI Knockout THP-1 Cell Line | EDJ-KZ368 | Human | 9111 | Details Get a Quote |
