NME6: NME/NM23 Nucleoside Diphosphate Kinase 6
A member of the NM23 family involved in nucleotide metabolism and potential tumor suppression.
Gene Information Card
| Symbol | NME6 |
|---|---|
| Full Name | NME/NM23 Nucleoside Diphosphate Kinase 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 10201 ncbi.nlm.nih.gov/gene/10201 |
| Ensembl ID | ENSG00000144554 |
| UniProt ID | Q9Y5N6 |
| OMIM ID | 608610 |
| HGNC ID | 7850 |
| Aliases | NM23-H6, NDK 6, NDP kinase 6 |
Description
NME6 (NME/NM23 Nucleoside Diphosphate Kinase 6) encodes a member of the NM23 family of nucleoside diphosphate kinases (NDPKs). These enzymes catalyze the transfer of a phosphate group from a nucleoside triphosphate to a nucleoside diphosphate, maintaining intracellular nucleotide pools. NME6 is localized to mitochondria and is implicated in cellular differentiation, proliferation, and suppression of metastatic potential. Its expression is altered in various cancers, suggesting a role in tumor biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Reduced NME6 expression correlates with increased metastatic potential; possible tumor suppressor role. | PMID: 12384512 |
| Colorectal Cancer | Downregulation of NME6 associated with poor prognosis and advanced tumor stage. | PMID: 15604211 |
| Hepatocellular Carcinoma | Decreased NME6 expression linked to tumor progression and metastasis. | PMID: 17213841 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Heart | 6.1 | Low |
| Brain | 4.2 | Low |
| Lung | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| MCF7 | 9.7 | Breast cancer cell line |
| A549 | 6.4 | Lung cancer cell line |
| HEK293 | 5.1 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.244G>A (p.Gly82Ser) | Missense | 0.001% (gnomAD) | Unknown functional impact |
| c.328C>T (p.Arg110Trp) | Missense | 0.002% (gnomAD) | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in NME6.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in NME6.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in NME6.
View complete mutation data：
Gene Ontology (GO)
| • nucleoside diphosphate kinase activity (GO:0004550) | • ATP binding (GO:0005524) |
| • mitochondrion (GO:0005739) | • UTP biosynthetic process (GO:0006228) |
| • GTP biosynthetic process (GO:0006183) |
Pathways
• Nucleotide metabolism (Reactome: R-HSA-8956321)
• Pyrimidine metabolism (KEGG: hsa00240)
• Purine metabolism (KEGG: hsa00230)
Protein Summary
NME6 is a 186-amino acid protein (20.5 kDa) belonging to the NM23 family. It functions as a nucleoside diphosphate kinase, catalyzing the reversible transfer of a phosphate group from NTPs to NDPs. The protein is predominantly mitochondrial and is involved in maintaining nucleotide homeostasis. NME6 has been implicated in cellular differentiation and suppression of metastatic spread in certain cancers, though its precise molecular mechanisms remain under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NME6 Knockout HEK293 Cell Line | EDJ-KQ6946 | Human | 10201 | Details Get a Quote |
| NME6 Knockout A-549 Cell Line | EDJ-KQ31606 | Human | 10201 | Details Get a Quote |
| NME6 Knockout HCT 116 Cell Line | EDJ-KQ31607 | Human | 10201 | Details Get a Quote |
| NME6 Knockout HeLa Cell Line | EDJ-KQ31608 | Human | 10201 | Details Get a Quote |
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