NMB Gene - Neuromedin B: Function, Expression, and Disease Associations

NMB (Neuromedin B) is a protein-coding gene that encodes a neuropeptide belonging to the bombesin-like family. The encoded protein is a precursor that is proteolytically processed to generate the mature neuromedin B peptide, which acts as a ligand for the neuromedin B receptor (NMBR). This signaling pathway regulates smooth muscle contraction, exocrine gland secretion, and cell growth. NMB is implicated in various cancers, including lung, breast, and prostate cancer, where it can act as an autocrine growth factor.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• GPCR ligand binding (Reactome: R-HSA-375276)

• Signaling by GPCR (Reactome: R-HSA-372790)

• Neuropeptide signaling pathway (KEGG: hsa04728)

The NMB gene encodes a 121-amino-acid preproprotein that is cleaved to produce the mature neuromedin B peptide (23 amino acids). This peptide is a member of the bombesin-like family and binds specifically to the neuromedin B receptor (NMBR), a G-protein-coupled receptor. Activation of NMBR triggers intracellular calcium mobilization and MAPK signaling, influencing cell proliferation, migration, and secretion. NMB is expressed at low levels in normal tissues but is upregulated in several cancers, where it contributes to tumor growth and metastasis.