NLRP10
NLR Family Pyrin Domain Containing 10
Gene Information Card
| Symbol | NLRP10 |
|---|---|
| Full Name | NLR Family Pyrin Domain Containing 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 338322 ncbi.nlm.nih.gov/gene/338322 |
| Ensembl ID | ENSG00000150456 |
| UniProt ID | Q86W26 |
| OMIM ID | 609662 |
| HGNC ID | 22911 |
| Aliases | CLR11.1, NALP10, NOD8, PAN5, PYNOD |
Description
NLRP10 (NLR family pyrin domain containing 10) is a member of the NLR (nucleotide-binding domain and leucine-rich repeat containing) family. Unlike most NLRs, NLRP10 lacks a leucine-rich repeat (LRR) domain and is thought to act as a negative regulator of inflammation by inhibiting ASC-dependent inflammasome activation and NF-κB signaling. It is involved in innate immune responses and epithelial barrier function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Atopic Dermatitis | NLRP10 deficiency impairs skin barrier function and enhances inflammatory responses | ClinVar, NCBI |
| Inflammatory Bowel Disease | Reduced NLRP10 expression linked to dysregulated intestinal inflammation | NCBI, OMIM |
| Asthma | NLRP10 variants associated with altered airway inflammation | ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 2.3 | Low |
| Lung | 1.8 | Low |
| Small Intestine | 1.5 | Low |
| Colon | 1.2 | Low |
| Spleen | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HaCaT (keratinocytes) | 2.1 | Basal expression |
| A549 (lung epithelial) | 1.5 | Low expression |
| Caco-2 (intestinal epithelial) | 1.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Likely loss of function |
| c.337C>T (p.Arg113Trp) | missense | <0.01% | Unknown significance |
| c.682G>A (p.Glu228Lys) | missense | <0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
NLRP10 loss-of-function mutations impair negative regulation of inflammasome, leading to excessive inflammation.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• NOD-like receptor signaling pathway (KEGG: hsa04621)
• Inflammasome pathway (Reactome: R-HSA-622312)
Protein Summary
NLRP10 is a 654-amino acid protein containing an N-terminal pyrin domain (PYD) and a central NACHT domain but lacking the C-terminal LRR domain. It functions as a negative regulator of inflammasome activation by sequestering ASC and inhibiting caspase-1 activation. Expressed mainly in epithelial tissues, NLRP10 plays a role in maintaining barrier integrity and modulating inflammatory responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NLRP10 Knockout HEK293 Cell Line | EDJ-KQ14440 | Human | 338322 | Details Get a Quote |
| NLRP10 Knockout HeLa Cell Line | EDJ-KQ59604 | Human | 338322 | Details Get a Quote |
| NLRP10 Knockout A-549 Cell Line | EDJ-KQ68069 | Human | 338322 | Details Get a Quote |
| NLRP10 Knockout HCT 116 Cell Line | EDJ-KQ76446 | Human | 338322 | Details Get a Quote |
