NID2 Gene (Nidogen-2)
Extracellular Matrix Protein Involved in Basement Membrane Assembly and Cancer
Gene Information Card
| Symbol | NID2 |
|---|---|
| Full Name | Nidogen-2 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q22.1 |
| NCBI Gene ID | 22795 ncbi.nlm.nih.gov/gene/22795 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q14112 |
| OMIM ID | 605399 |
| HGNC ID | 7829 |
| Aliases | NID-2, nidogen 2 |
Description
NID2 encodes nidogen-2, a member of the nidogen family of basement membrane glycoproteins. Nidogen-2 binds to laminins, collagen IV, and perlecan, contributing to the structural integrity of basement membranes. It is involved in cell adhesion, migration, and tissue development. Altered expression is observed in various cancers and fibrotic diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered NID2 expression affects tumor microenvironment and metastasis | COSMIC, literature |
| Renal fibrosis | Upregulation of NID2 contributes to extracellular matrix remodeling | PubMed |
| Alport syndrome | NID2 mutations may modify basement membrane defects | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Lung | 8.3 | Medium |
| Heart | 6.1 | Low |
| Liver | 4.2 | Low |
| Brain | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | Embryonic kidney cells |
| A549 | 9.5 | Lung carcinoma |
| MCF7 | 3.2 | Breast cancer |
| HepG2 | 2.1 | Hepatocellular carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | <0.1% | Unknown functional impact |
| c.567delA | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to truncated protein
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
Pathways
• ECM-receptor interaction (KEGG: hsa04512)
• Focal adhesion (KEGG: hsa04510)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
Protein Summary
Nidogen-2 is a 150 kDa glycoprotein that forms a dumbbell-shaped structure with three globular domains (G1, G2, G3). It bridges laminin and collagen IV networks in basement membranes. The G2 domain binds perlecan, while G3 interacts with laminin. Nidogen-2 is essential for basement membrane assembly during development and tissue homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NID2 Knockout HEK293 Cell Line | EDJ-KQ3713 | Human | 22795 | Details Get a Quote |
| NID2 Knockout A-549 Cell Line | EDJ-KQ25744 | Human | 22795 | Details Get a Quote |
| NID2 Knockout HeLa Cell Line | EDJ-KQ25745 | Human | 22795 | Details Get a Quote |
| NID2 Knockout HCT 116 Cell Line | EDJ-KQ72580 | Human | 22795 | Details Get a Quote |
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