NGFR (Nerve Growth Factor Receptor)
A key regulator of neuronal survival, differentiation, and cell death, implicated in cancer and neurodegenerative disorders.
Gene Information Card
| Symbol | NGFR |
|---|---|
| Full Name | Nerve Growth Factor Receptor |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.33 |
| NCBI Gene ID | 4804 ncbi.nlm.nih.gov/gene/4804 |
| Ensembl ID | ENSG00000064300 |
| UniProt ID | P08138 |
| OMIM ID | 162010 |
| HGNC ID | 7809 |
| Aliases | p75NTR, TNFRSF16, CD271, Gp80-LNGFR |
Description
The NGFR gene encodes the low-affinity nerve growth factor receptor (p75NTR), a member of the tumor necrosis factor receptor superfamily. It binds neurotrophins (NGF, BDNF, NT-3, NT-4) and modulates neuronal survival, apoptosis, axonal growth, and synaptic plasticity. NGFR also plays roles in non-neuronal tissues, including immune regulation and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Alzheimer disease | NGFR signaling dysregulation contributes to amyloid-beta toxicity and neuronal loss | PMID: 21943603 |
| Breast cancer | NGFR overexpression promotes tumor cell survival and metastasis via NF-kB activation | PMID: 25624456 |
| Neuroblastoma | NGFR mutations and altered expression correlate with poor prognosis | COSMIC: NGFR |
| Congenital insensitivity to pain with anhidrosis (CIPA) | Loss-of-function mutations in NGFR impair NGF-dependent nociceptor development | OMIM: 162010 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Adipose tissue | 8.7 | Low |
| Lung | 6.2 | Low |
| Skin | 15.1 | Medium |
| Prostate | 4.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 18.9 | Neuroblastoma cell line |
| MCF7 | 7.3 | Breast cancer cell line |
| HEK293 | 2.1 | Embryonic kidney |
| A549 | 5.6 | Lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.104C>T (p.Thr35Met) | Missense | <0.01% | Reduced NGF binding affinity |
| c.473G>A (p.Arg158His) | Missense | 0.02% | Impaired receptor dimerization |
| c.832C>T (p.Arg278Cys) | Missense | <0.01% | Loss of function in CIPA |
Mutation functional classification
Loss of Function (LOF)
Missense mutations (e.g., p.Arg278Cys) disrupt NGF binding and downstream signaling, leading to CIPA.
Gain of Function (GOF)
Not well documented; overexpression in cancers may confer gain-of-function via constitutive NF-kB activation.
Dominant Negative (DN)
Truncated isoforms or certain missense variants (e.g., p.Arg158His) can interfere with wild-type receptor function.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Neurotrophin signaling pathway (KEGG: hsa04722)
• Apoptosis (KEGG: hsa04210)
• NF-kB signaling (Reactome: R-HSA-975110)
Protein Summary
The NGFR protein (p75NTR) is a 75 kDa transmembrane receptor with an extracellular cysteine-rich domain and an intracellular death domain. It interacts with Trk receptors to modulate neurotrophin signaling, promoting either cell survival or apoptosis depending on cellular context. p75NTR also binds proneurotrophins with high affinity, mediating neuronal cell death in development and disease.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NGFR Knockout HEK293 Cell Line | EDJ-KQ210 | Human | 4804 | Details Get a Quote |
| NGFR Knockout HCT 116 Cell Line | EDJ-KQ19331 | Human | 4804 | Details Get a Quote |
| NGFR Knockout SCC-9 Cell Line | EDJ-KZ365 | Human | 4804 | Details Get a Quote |
| NGFR Knockout HeLa Cell Line | EDJ-KQ53991 | Human | 4804 | Details Get a Quote |
| NGFR Knockout A-549 Cell Line | EDJ-KQ62484 | Human | 4804 | Details Get a Quote |
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