NGB (Neuroglobin)
A globin family member involved in oxygen transport and neuroprotection
Gene Information Card
| Symbol | NGB |
|---|---|
| Full Name | Neuroglobin |
| Gene Type | protein-coding |
| Chromosomal Location | 14q24.3 |
| NCBI Gene ID | 58157 ncbi.nlm.nih.gov/gene/58157 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q9NPG2 |
| OMIM ID | 605304 |
| HGNC ID | 15677 |
| Aliases | NGB, neuroglobin |
Description
NGB encodes neuroglobin, a member of the globin family that binds oxygen reversibly. It is predominantly expressed in the brain and retina, where it may protect neurons from hypoxic-ischemic injury. Neuroglobin is involved in oxygen transport, nitric oxide scavenging, and inhibition of apoptosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Alzheimer disease | Reduced NGB expression may impair neuronal oxygen homeostasis and increase oxidative stress | PMID: 20085779 |
| Ischemic stroke | NGB upregulation in response to hypoxia may limit neuronal damage | PMID: 12808427 |
| Retinal ischemia | NGB protects retinal ganglion cells from hypoxia-induced apoptosis | PMID: 15001782 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | High |
| Retina | 8.7 | Medium |
| Heart | 2.1 | Low |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.6 | High expression |
| U-87 MG (glioblastoma) | 9.8 | Moderate expression |
| HEK293 (embryonic kidney) | 1.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.293C>T (p.Ala98Val) | missense | <0.01% | Reduced oxygen affinity in vitro |
| c.376G>A (p.Gly126Ser) | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
p.Ala98Val reduces oxygen binding capacity
Gain of Function (GOF)
None reported
Dominant Negative (DN)
None reported
View complete mutation data：
Gene Ontology (GO)
Pathways
• Oxygen transport (Reactome: R-HSA-1483206)
• Cellular response to hypoxia (KEGG: hsa04066)
Protein Summary
Neuroglobin is a 151-amino acid monomeric globin with a heme prosthetic group. It exhibits a typical globin fold with a distal histidine that stabilizes bound oxygen. The protein is primarily cytosolic but can translocate to the nucleus under stress. It has a higher oxygen affinity than hemoglobin and myoglobin, and its expression is induced by hypoxia via HIF-1α.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CNGB1 Knockout HEK293 Cell Line | EDJ-KQ1804 | Human | 1258 | Details Get a Quote |
| CNGB3 Knockout HEK293 Cell Line | EDJ-KQ1805 | Human | 54714 | Details Get a Quote |
| NGB Knockout HEK293 Cell Line | EDJ-KQ12053 | Human | 58157 | Details Get a Quote |
| CNGB1 Knockout HeLa Cell Line | EDJ-KQ52940 | Human | 1258 | Details Get a Quote |
| CNGB3 Knockout HeLa Cell Line | EDJ-KQ56458 | Human | 54714 | Details Get a Quote |
| NGB Knockout HeLa Cell Line | EDJ-KQ56930 | Human | 58157 | Details Get a Quote |
| CNGB1 Knockout A-549 Cell Line | EDJ-KQ61406 | Human | 1258 | Details Get a Quote |
| CNGB3 Knockout A-549 Cell Line | EDJ-KQ64951 | Human | 54714 | Details Get a Quote |
| NGB Knockout A-549 Cell Line | EDJ-KQ65435 | Human | 58157 | Details Get a Quote |
| CNGB1 Knockout HCT 116 Cell Line | EDJ-KQ69901 | Human | 1258 | Details Get a Quote |
| CNGB3 Knockout HCT 116 Cell Line | EDJ-KQ73396 | Human | 54714 | Details Get a Quote |
| NGB Knockout HCT 116 Cell Line | EDJ-KQ73873 | Human | 58157 | Details Get a Quote |
Displaying Records 1 To 12 Of 12 Records
