NES (Nestin) Gene
Intermediate Filament Protein Marker for Neural Stem Cells
Gene Information Card
| Symbol | NES |
|---|---|
| Full Name | Nestin |
| Gene Type | protein-coding |
| Chromosomal Location | 1q23.1 |
| NCBI Gene ID | 10763 ncbi.nlm.nih.gov/gene/10763 |
| Ensembl ID | ENSG00000132688 |
| UniProt ID | P48681 |
| OMIM ID | 600915 |
| HGNC ID | 7756 |
| Aliases | FLJ21841, Nbla00170 |
Description
NES (nestin) encodes an intermediate filament protein expressed primarily in neural stem cells and progenitor cells during development. It is downregulated upon differentiation but re-expressed in certain cancers, particularly gliomas, where it serves as a marker of stemness and poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioma | Re-expression of nestin in glioma cells correlates with tumor grade and stem cell phenotype. | PMID: 19010870 |
| Glioblastoma | High NES expression is associated with aggressive tumor behavior and shorter survival. | PMID: 23573287 |
| Pancreatic cancer | Nestin expression in pancreatic stellate cells may promote tumor progression. | PMID: 20593220 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.0 | Not detected |
| Cerebral cortex | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Placenta | 0.0 | Not detected |
| Skeletal muscle | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 0.0 | Neuroblastoma cell line; no detectable NES expression |
| U-87 MG | 0.0 | Glioblastoma cell line; low/undetectable in standard culture |
| A549 | 0.0 | Lung carcinoma cell line; no expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown significance |
| c.100C>T | missense | <0.1% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
No established loss-of-function mutations reported in NES.
Gain of Function (GOF)
No established gain-of-function mutations reported in NES.
Dominant Negative (DN)
No dominant-negative mutations reported in NES.
View complete mutation data：
Gene Ontology (GO)
| • structural molecule activity (GO:0005198) | • intermediate filament (GO:0005882) |
| • cytoplasm (GO:0005737) | • intermediate filament organization (GO:0045109) |
Pathways
• Intermediate filament cytoskeleton (Reactome: R-HSA-6809371)
Protein Summary
Nestin is a class VI intermediate filament protein of ~177 kDa. It forms heteropolymers with other intermediate filament proteins such as vimentin and internexin. Nestin is essential for the radial growth of axons and is a widely used marker for neural stem and progenitor cells. Its re-expression in various cancers, especially gliomas, makes it a potential diagnostic and prognostic biomarker.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NES Knockout HEK293 Cell Line | EDJ-KQ3620 | Human | 10763 | Details Get a Quote |
| NES Knockout HCT 116 Cell Line | EDJ-KQ24180 | Human | 10763 | Details Get a Quote |
| NES Knockout A-549 Cell Line | EDJ-KQ25556 | Human | 10763 | Details Get a Quote |
| NES Knockout HeLa Cell Line | EDJ-KQ25558 | Human | 10763 | Details Get a Quote |
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