NENF (Neudesin) Gene
Neurotrophic factor and potential biomarker in cancer and neurological disorders
Gene Information Card
| Symbol | NENF |
|---|---|
| Full Name | neudesin neurotrophic factor |
| Gene Type | protein-coding |
| Chromosomal Location | 1q32.3 |
| NCBI Gene ID | 29937 ncbi.nlm.nih.gov/gene/29937 |
| Ensembl ID | ENSG00000117676 |
| UniProt ID | Q9UHV7 |
| OMIM ID | 617393 |
| HGNC ID | 30323 |
| Aliases | C1orf128, SPUF, neudesin |
Description
NENF (neudesin neurotrophic factor) encodes a secreted protein with neurotrophic activity, promoting neuronal survival and differentiation. It is also implicated in cancer progression and metabolic regulation. The gene is located on chromosome 1q32.3 and is conserved across vertebrates.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of NENF promotes cell proliferation and migration via MAPK/ERK signaling | PMID: 25620004 |
| Colorectal cancer | NENF upregulation associated with poor prognosis and tumor growth | PMID: 30348635 |
| Alzheimer's disease | Reduced NENF expression may impair neuroprotection | PMID: 22493020 |
| Major depressive disorder | NENF levels altered in brain regions linked to mood regulation | PMID: 25620004 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 3.1 | Low |
| Kidney | 6.7 | Low |
| Lung | 4.9 | Low |
| Breast | 15.2 | Medium |
| Colon | 11.8 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 18.4 | High expression |
| HCT116 (colorectal cancer) | 14.2 | Moderate expression |
| SH-SY5Y (neuroblastoma) | 22.1 | High expression |
| HEK293 (embryonic kidney) | 9.7 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.236C>T (p.Pro79Leu) | Missense | <0.01% | Unknown functional impact |
| c.412G>A (p.Val138Ile) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in NENF.
Gain of Function (GOF)
Overexpression in cancer suggests potential gain-of-function role in tumorigenesis.
Dominant Negative (DN)
No dominant-negative mutations described for NENF.
View complete mutation data：
Gene Ontology (GO)
| • growth factor activity (GO:0008083) | • extracellular region (GO:0005576) |
| • nervous system development (GO:0007399) | • regulation of neuron apoptotic process (GO:0043523) |
Pathways
• MAPK signaling pathway (Reactome: R-HSA-5687128)
• Signaling by NGF (Reactome: R-HSA-166520)
Protein Summary
Neudesin is a secreted 172-amino acid protein containing a cytochrome b5-like heme-binding domain. It acts as a neurotrophic factor, promoting survival of neurons and glial cells. In cancer, neudesin enhances cell proliferation and migration through MAPK/ERK and PI3K/Akt pathways. It is also involved in energy metabolism and adipocyte function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NENF Knockout HEK293 Cell Line | EDJ-KQ8334 | Human | 29937 | Details Get a Quote |
| NENF Knockout A-549 Cell Line | EDJ-KQ35587 | Human | 29937 | Details Get a Quote |
| NENF Knockout HCT 116 Cell Line | EDJ-KQ35589 | Human | 29937 | Details Get a Quote |
| NENF Knockout HeLa Cell Line | EDJ-KQ35590 | Human | 29937 | Details Get a Quote |
