NCOA7
Nuclear Receptor Coactivator 7
Gene Information Card
| Symbol | NCOA7 |
|---|---|
| Full Name | Nuclear Receptor Coactivator 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 6q22.31 |
| NCBI Gene ID | 135112 ncbi.nlm.nih.gov/gene/135112 |
| Ensembl ID | ENSG00000111913 |
| UniProt ID | Q8NI08 |
| OMIM ID | 609752 |
| HGNC ID | 21015 |
| Aliases | ERAP140, NCOA7-AS, dJ187J11.3 |
Description
NCOA7 (nuclear receptor coactivator 7) encodes a protein that functions as a transcriptional coactivator for nuclear receptors, including estrogen receptor alpha. It interacts with nuclear receptors and other transcription factors to enhance gene expression. The protein contains a nuclear receptor interaction domain and may play a role in hormone signaling and cellular metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | NCOA7 expression is altered in breast cancer; may modulate estrogen receptor signaling | ClinVar, COSMIC |
| Ovarian cancer | Somatic mutations and copy number alterations reported | COSMIC |
| Prostate cancer | Potential role in androgen receptor coactivation | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 10.2 | Medium |
| Ovary | 8.5 | Medium |
| Prostate | 7.1 | Low |
| Liver | 6.3 | Low |
| Brain | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 | 12.5 | Breast cancer cell line |
| HeLa | 9.8 | Cervical cancer cell line |
| HepG2 | 7.2 | Liver cancer cell line |
| LNCaP | 6.9 | Prostate cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | 0.02% | p.Pro412Ser; uncertain significance |
| c.567_568del | Frameshift | 0.01% | Loss of function |
| c.890A>G | Missense | 0.03% | p.Asn297Ser; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.567_568del) predicted to cause loss of coactivator function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • nuclear receptor coactivator activity | • transcription coactivator activity |
| • protein binding | • nucleus |
| • cytoplasm |
Pathways
• Nuclear receptor signaling pathway
• Estrogen signaling pathway
Protein Summary
NCOA7 is a 140 kDa nuclear receptor coactivator that enhances transcription mediated by nuclear receptors such as estrogen receptor alpha. It contains an LXXLL motif for receptor interaction and localizes to the nucleus. The protein is involved in hormone-dependent gene regulation and may influence cancer cell proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NCOA7 Knockout HEK293 Cell Line | EDJ-KQ9352 | Human | 135112 | Details Get a Quote |
| NCOA7 Knockout A-549 Cell Line | EDJ-KQ35994 | Human | 135112 | Details Get a Quote |
| NCOA7 Knockout HCT 116 Cell Line | EDJ-KQ35995 | Human | 135112 | Details Get a Quote |
| NCOA7 Knockout HeLa Cell Line | EDJ-KQ34740 | Human | 135112 | Details Get a Quote |
