NCOA1
Nuclear Receptor Coactivator 1
Gene Information Card
| Symbol | NCOA1 |
|---|---|
| Full Name | Nuclear Receptor Coactivator 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 2p23.3 |
| NCBI Gene ID | 8648 ncbi.nlm.nih.gov/gene/8648 |
| Ensembl ID | ENSG00000084676 |
| UniProt ID | Q15788 |
| OMIM ID | 602691 |
| HGNC ID | 7668 |
| Aliases | SRC-1, bHLHe42, F-SRC-1, KAT13A, NCoA-1, RIP160 |
Description
NCOA1 (nuclear receptor coactivator 1) encodes a transcriptional coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activity. The protein possesses histone acetyltransferase activity and is involved in chromatin remodeling, playing critical roles in development, metabolism, and hormone signaling. NCOA1 is also known as steroid receptor coactivator-1 (SRC-1).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | NCOA1 amplification/overexpression enhances estrogen receptor signaling, promoting tumor growth | PMID: 10629051 |
| Prostate cancer | NCOA1 coactivates androgen receptor, linked to hormone therapy resistance | PMID: 11877377 |
| Endometrial cancer | NCOA1 overexpression correlates with poor prognosis and hormone receptor activity | PMID: 15604223 |
| Obesity | NCOA1 knockout mice show resistance to diet-induced obesity, suggesting role in energy balance | PMID: 11867748 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 12.3 | Medium |
| Prostate | 8.7 | Medium |
| Uterus | 15.1 | High |
| Brain | 6.2 | Low |
| Liver | 4.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 18.5 | High expression |
| LNCaP (prostate cancer) | 14.2 | High expression |
| HepG2 (liver cancer) | 5.1 | Low expression |
| HeLa (cervical cancer) | 9.8 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.2110G>A (p.Glu704Lys) | Missense | <0.1% | Unknown functional effect |
| c.3823C>T (p.Arg1275Trp) | Missense | <0.1% | Reported in COSMIC |
| Amplification | Copy number gain | ~5% in breast cancer | Increased coactivator activity |
Mutation functional classification
Loss of Function (LOF)
Rare truncating mutations may reduce coactivator activity, but not well characterized.
Gain of Function (GOF)
Gene amplification and overexpression enhance nuclear receptor signaling, linked to cancer progression.
Dominant Negative (DN)
Not reported for NCOA1.
View complete mutation data：
Gene Ontology (GO)
| • nuclear receptor coactivator activity | • histone acetyltransferase activity |
| • transcription coactivator activity | • chromatin binding |
| • protein binding | • nucleus |
Pathways
• Nuclear receptor signaling pathway
• Estrogen signaling pathway
• Androgen receptor signaling pathway
• Notch signaling pathway
Protein Summary
NCOA1 (SRC-1) is a 1441-amino acid nuclear receptor coactivator with intrinsic histone acetyltransferase activity. It contains multiple LXXLL motifs for receptor interaction, a basic helix-loop-helix domain, and a glutamine-rich region. The protein enhances transcription by recruiting additional coactivators and remodeling chromatin. It is widely expressed and plays key roles in hormone-dependent cancers and metabolic regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NCOA1 Knockout HEK293 Cell Line | EDJ-KQ6316 | Human | 8648 | Details Get a Quote |
| NCOA1 Knockout A-549 Cell Line | EDJ-KQ30236 | Human | 8648 | Details Get a Quote |
| NCOA1 Knockout HCT 116 Cell Line | EDJ-KQ30237 | Human | 8648 | Details Get a Quote |
| NCOA1 Knockout HeLa Cell Line | EDJ-KQ30238 | Human | 8648 | Details Get a Quote |
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