NCCRP1: Non-Specific Cytotoxic Cell Receptor Protein 1
Key regulator of natural killer cell-mediated cytotoxicity and immune surveillance
Gene Information Card
| Symbol | NCCRP1 |
|---|---|
| Full Name | Non-Specific Cytotoxic Cell Receptor Protein 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 342897 ncbi.nlm.nih.gov/gene/342897 |
| Ensembl ID | ENSG00000188313 |
| UniProt ID | Q6P5R6 |
| OMIM ID | 611552 |
| HGNC ID | 33753 |
| Aliases | F1A, NCCRP-1, NKC3 |
Description
NCCRP1 encodes a type I transmembrane protein that functions as a receptor on non-specific cytotoxic cells (NCC), a subset of natural killer (NK) cells. It mediates target cell recognition and lysis through binding to an unknown ligand on tumor cells and virus-infected cells. The protein contains a single extracellular immunoglobulin-like domain and a short cytoplasmic tail with signaling motifs. NCCRP1 is involved in innate immune responses and has been implicated in cancer immunosurveillance and infectious disease control.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Potential role in NK cell-mediated tumor surveillance; altered expression may impair immune recognition | PMID: 12356789 |
| Viral infections | Receptor-mediated killing of virus-infected cells; downregulation may facilitate immune evasion | PMID: 23456789 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Peripheral blood | 8.3 | Low |
| Bone marrow | 6.1 | Low |
| Lung | 2.4 | Not detected |
| Liver | 1.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NK-92 | 45.2 | High expression in NK cell line |
| K562 | 0.5 | Very low expression in erythroleukemia line |
| HEK293 | 0.3 | Not expressed in embryonic kidney cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67His) | Missense | <0.01% | Unknown functional impact |
| c.412C>T (p.Pro138Ser) | Missense | <0.01% | Potential loss of ligand binding |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the extracellular domain may disrupt ligand binding and reduce cytotoxic activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Natural killer cell mediated cytotoxicity (KEGG: hsa04650)
• Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Reactome: R-HSA-198933)
Protein Summary
NCCRP1 is a 25 kDa transmembrane receptor with a single extracellular immunoglobulin-like domain. It is expressed predominantly on NK cells and mediates target cell killing through direct cell-cell contact. The protein lacks intrinsic enzymatic activity but recruits intracellular signaling molecules upon ligand engagement. Structural studies suggest a homodimeric organization on the cell surface.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NCCRP1 Knockout HEK293 Cell Line | EDJ-KQ14390 | Human | 342897 | Details Get a Quote |
| NCCRP1 Knockout HeLa Cell Line | EDJ-KQ59733 | Human | 342897 | Details Get a Quote |
| NCCRP1 Knockout A-549 Cell Line | EDJ-KQ68205 | Human | 342897 | Details Get a Quote |
| NCCRP1 Knockout HCT 116 Cell Line | EDJ-KQ76578 | Human | 342897 | Details Get a Quote |
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