NAT9: N-Acetyltransferase 9 (Putative)
A member of the N-acetyltransferase family with potential roles in cellular metabolism and disease.
Gene Information Card
| Symbol | NAT9 |
|---|---|
| Full Name | N-acetyltransferase 9 (putative) |
| Gene Type | protein-coding |
| Chromosomal Location | 17q25.1 |
| NCBI Gene ID | 26151 ncbi.nlm.nih.gov/gene/26151 |
| Ensembl ID | ENSG00000109062 |
| UniProt ID | Q9BTE0 |
| OMIM ID | 608703 |
| HGNC ID | 18033 |
| Aliases | NAT9, N-acetyltransferase 9, NAL1, N-acetyltransferase-like 1 |
Description
NAT9 (N-acetyltransferase 9) is a protein-coding gene located on chromosome 17q25.1. It encodes a putative N-acetyltransferase enzyme belonging to the GCN5-related N-acetyltransferase (GNAT) family. The protein is predicted to catalyze the transfer of acetyl groups from acetyl-CoA to substrate amines, though its specific biological substrates and functions remain under investigation. NAT9 is ubiquitously expressed and has been implicated in cellular processes including metabolism and protein modification.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered NAT9 expression may affect acetylation pathways involved in cell proliferation and survival. | COSMIC; limited direct evidence |
| No specific Mendelian disease association | NAT9 is not currently linked to a monogenic disorder in OMIM. | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 10.2 | Medium |
| Adrenal gland | 9.8 | Medium |
| Liver | 8.5 | Medium |
| Brain | 6.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | Moderate expression |
| HeLa | 12.0 | Moderate expression |
| K562 | 8.0 | Low expression |
| A549 | 7.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.307G>A (p.Gly103Arg) | Missense | <0.01% | Unknown; predicted benign by in silico tools |
| c.421C>T (p.Arg141Trp) | Missense | <0.01% | Unknown; predicted possibly damaging |
| c.544_546del (p.Lys182del) | In-frame deletion | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in NAT9.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • N-acetyltransferase activity (GO:0008080) | • cytoplasm (GO:0005737) |
| • nucleoplasm (GO:0005654) | • protein binding (GO:0005515) |
Pathways
• No specific curated pathways for NAT9 in major databases.
Protein Summary
NAT9 encodes a 207-amino acid protein with a predicted molecular weight of ~23 kDa. It contains a conserved N-acetyltransferase domain characteristic of the GNAT superfamily. The protein is localized to the cytoplasm and nucleus, and is ubiquitously expressed. Its exact catalytic function and substrate specificity remain to be fully elucidated, but it is hypothesized to participate in acetylation-dependent cellular regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NAT9 Knockout HEK293 Cell Line | EDJ-KQ8434 | Human | 26151 | Details Get a Quote |
| NAT9 Knockout A-549 Cell Line | EDJ-KQ34548 | Human | 26151 | Details Get a Quote |
| NAT9 Knockout HCT 116 Cell Line | EDJ-KQ34549 | Human | 26151 | Details Get a Quote |
| NAT9 Knockout HeLa Cell Line | EDJ-KQ34550 | Human | 26151 | Details Get a Quote |
