NAT14
N-Acetyltransferase 14 (Putative)
Gene Information Card
| Symbol | NAT14 |
|---|---|
| Full Name | N-acetyltransferase 14 (putative) |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 57106 ncbi.nlm.nih.gov/gene/57106 |
| Ensembl ID | ENSG00000104879 |
| UniProt ID | Q8N1F7 |
| OMIM ID | 615322 |
| HGNC ID | 25976 |
| Aliases | FLJ20489, MGC138499, MGC138500 |
Description
NAT14 is a putative N-acetyltransferase gene located on chromosome 19q13.33. It encodes a protein predicted to catalyze the transfer of acetyl groups to substrates, though its specific biological function and substrates remain incompletely characterized. The gene is expressed in multiple tissues and has been implicated in certain cancers based on expression and mutation data.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Overexpression observed in tumor samples; potential role in acetylation pathways | COSMIC, literature |
| Colorectal Cancer | Altered expression levels reported; functional significance unclear | COSMIC, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Testis | 8.9 | Low |
| Brain | 6.1 | Low |
| Heart | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 14.3 | Liver cancer cell line |
| HEK293 | 11.7 | Embryonic kidney |
| MCF7 | 9.8 | Breast cancer cell line |
| A549 | 7.2 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.100C>T | Synonymous | <0.01% | No predicted effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • N-acetyltransferase activity (GO:0008080) | • cytoplasm (GO:0005737) |
Pathways
• No specific pathways curated in major databases.
Protein Summary
The NAT14 protein (UniProt Q8N1F7) is a putative N-acetyltransferase of 207 amino acids. It contains a conserved N-acetyltransferase domain and is predicted to localize to the cytoplasm. Its exact catalytic function and substrate specificity remain under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NAT14 Knockout HEK293 Cell Line | EDJ-KQ14376 | Human | 57106 | Details Get a Quote |
| NAT14 Knockout A-549 Cell Line | EDJ-KQ44521 | Human | 57106 | Details Get a Quote |
| NAT14 Knockout HCT 116 Cell Line | EDJ-KQ44522 | Human | 57106 | Details Get a Quote |
| NAT14 Knockout HeLa Cell Line | EDJ-KQ44523 | Human | 57106 | Details Get a Quote |
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