NAP1L1 Gene - Nucleosome Assembly Protein 1 Like 1
A comprehensive biomedical resource for NAP1L1, including gene card, expression, mutations, and disease associations.
Gene Information Card
| Symbol | NAP1L1 |
|---|---|
| Full Name | Nucleosome Assembly Protein 1 Like 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 12q21.1 |
| NCBI Gene ID | 4673 ncbi.nlm.nih.gov/gene/4673 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | P55209 |
| OMIM ID | 600982 |
| HGNC ID | 7637 |
| Aliases | NAP1, NAP1L, hNRP |
Description
NAP1L1 (Nucleosome Assembly Protein 1 Like 1) is a protein-coding gene that encodes a member of the nucleosome assembly protein (NAP) family. This protein functions as a histone chaperone, facilitating the transport and deposition of histones H2A and H2B into nucleosomes, thereby playing a critical role in chromatin assembly, DNA replication, and transcriptional regulation. NAP1L1 is ubiquitously expressed and has been implicated in cell cycle progression and oncogenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Overexpression of NAP1L1 promotes cell proliferation and migration via chromatin remodeling and transcriptional activation of oncogenes. | NCBI Gene, COSMIC |
| Hepatocellular Carcinoma | Upregulation of NAP1L1 correlates with poor prognosis and enhanced tumor growth through histone chaperone activity. | NCBI Gene, COSMIC |
| Breast Cancer | NAP1L1 overexpression is associated with aggressive tumor phenotypes and may influence estrogen receptor signaling. | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 45.2 | High |
| Bone Marrow | 32.1 | High |
| Lymph Node | 28.7 | High |
| Brain | 15.3 | Medium |
| Liver | 12.8 | Medium |
| Heart | 8.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 (leukemia) | 52.3 | High expression |
| HeLa (cervical) | 38.9 | High expression |
| HepG2 (liver) | 22.1 | Medium expression |
| MCF7 (breast) | 18.5 | Medium expression |
| A549 (lung) | 14.2 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | Missense | <0.01% | Unknown; likely benign |
| c.544C>T (p.Arg182Trp) | Missense | <0.01% | Unknown; reported in COSMIC |
| c.763_764insA (p.Thr255Asnfs*2) | Frameshift | <0.01% | Loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.763_764insA) are predicted to cause loss of histone chaperone activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported for NAP1L1.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for NAP1L1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Nucleosome assembly (REACT_1798)
• Chromatin modifying enzymes (REACT_1837)
• Cell cycle (REACT_152)
Protein Summary
The NAP1L1 protein (UniProt P55209) is a 391-amino acid histone chaperone that shuttles between the nucleus and cytoplasm. It binds specifically to histones H2A and H2B, facilitating their incorporation into nucleosomes during DNA replication and repair. NAP1L1 also interacts with importins and exportins to regulate its subcellular localization. The protein is highly conserved across eukaryotes and is essential for proper chromatin dynamics.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NAP1L1 Knockout HEK293 Cell Line | EDJ-KQ50463 | Human | 4673 | Details Get a Quote |
| NAP1L1 Knockout HeLa Cell Line | EDJ-KQ53960 | Human | 4673 | Details Get a Quote |
| NAP1L1 Knockout A-549 Cell Line | EDJ-KQ62450 | Human | 4673 | Details Get a Quote |
| NAP1L1 Knockout HCT 116 Cell Line | EDJ-KQ70915 | Human | 4673 | Details Get a Quote |
