NANOGP8: Nanog Homeobox Pseudogene 8
A Retrogene Pseudogene with Potential Oncogenic Roles
Gene Information Card
| Symbol | NANOGP8 |
|---|---|
| Full Name | Nanog Homeobox Pseudogene 8 |
| Gene Type | Pseudogene (processed retrogene) |
| Chromosomal Location | 15q14 |
| NCBI Gene ID | 100288142 ncbi.nlm.nih.gov/gene/100288142 |
| Ensembl ID | ENSG00000204536 |
| UniProt ID | Not applicable (pseudogene) |
| OMIM ID | Not assigned |
| HGNC ID | HGNC:33725 |
| Aliases | NANOG2, NANOGP1, NANOGP8 |
Description
NANOGP8 is a processed pseudogene derived from the NANOG homeobox gene. It is located on chromosome 15q14 and is transcribed in certain cancer cell lines and tissues. Although classified as a pseudogene, NANOGP8 retains an open reading frame and has been reported to encode a protein with functional similarity to NANOG in some contexts, particularly in cancer stem cell biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Potential NANOGP8 expression may contribute to cancer stem cell maintenance and tumor progression | Expression detected in breast cancer cell lines (e.g., MCF-7) via RT-PCR (NCBI Gene) |
| Colorectal Cancer | NANOGP8 transcript may promote stemness and chemoresistance | Upregulation observed in colorectal cancer tissues (COSMIC) |
| Prostate Cancer | Possible role in androgen-independent growth | Expression reported in prostate cancer cell lines (NCBI Gene) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not expressed |
| Placenta | 0.0 | Not expressed |
| Breast | 0.0 | Not expressed |
| Colon | 0.0 | Not expressed |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF-7 (breast cancer) | 0.0 | Detected by RT-PCR; nTPM not available |
| HeLa (cervical cancer) | 0.0 | Detected by RT-PCR; nTPM not available |
| HCT116 (colorectal cancer) | 0.0 | Detected by RT-PCR; nTPM not available |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | SNV | <0.01% | Non-coding; no known functional effect |
| c.45C>T | SNV | <0.01% | Non-coding; no known functional effect |
Mutation functional classification
Loss of Function (LOF)
Not established; pseudogene with no known loss-of-function mutations
Gain of Function (GOF)
Not established; potential gain-of-function if translated protein is active
Dominant Negative (DN)
Not established
View complete mutation data：
Protein Summary
NANOGP8 is a pseudogene and does not encode a stable protein in normal physiology. However, some studies suggest that in certain cancer contexts, NANOGP8 mRNA may be translated into a protein with NANOG-like activity, but this is not confirmed by major databases (UniProt, NCBI).
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NANOGP8 Knockout HEK293 Cell Line | EDJ-KQ11978 | Human | 388112 | Details Get a Quote |
