NAA16: N-alpha-acetyltransferase 16, NatA auxiliary subunit
A regulatory subunit of the N-terminal acetyltransferase A (NatA) complex involved in co-translational protein acetylation.
Gene Information Card
| Symbol | NAA16 |
|---|---|
| Full Name | N-alpha-acetyltransferase 16, NatA auxiliary subunit |
| Gene Type | protein-coding |
| Chromosomal Location | 13q14.11 |
| NCBI Gene ID | 79612 ncbi.nlm.nih.gov/gene/79612 |
| Ensembl ID | ENSG00000170260 |
| UniProt ID | Q6N069 |
| OMIM ID | 616215 |
| HGNC ID | 25168 |
| Aliases | MGC10744, NAT16, NAA16P, hNaa16p |
Description
NAA16 encodes a regulatory subunit of the N-terminal acetyltransferase A (NatA) complex. The NatA complex catalyzes co-translational acetylation of nascent polypeptides after removal of the initiator methionine. NAA16 is an auxiliary subunit that modulates substrate specificity and complex stability. It is ubiquitously expressed with highest levels in testis and brain.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered NatA activity may affect acetylation of oncoproteins and tumor suppressors. | COSMIC; literature review |
| Neurodevelopmental disorders | Variants in NAA16 have been associated with intellectual disability and developmental delay. | ClinVar; OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 28.5 | High |
| Brain | 15.2 | Medium |
| Heart | 10.8 | Medium |
| Liver | 6.3 | Low |
| Kidney | 7.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.4 | Embryonic kidney cells |
| HeLa | 9.8 | Cervical carcinoma cells |
| K562 | 8.1 | Leukemia cells |
| HepG2 | 5.6 | Hepatocellular carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T (p.Arg349*) | Nonsense | <0.01% | Loss of function; truncated protein |
| c.788A>G (p.Asn263Ser) | Missense | <0.01% | Unknown; possibly damaging (PolyPhen-2) |
| c.1234_1235del (p.Lys412Glufs*3) | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations lead to truncated or absent NAA16 protein, impairing NatA complex assembly and activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
Not established; potential dominant-negative effects of missense variants remain uncharacterized.
View complete mutation data：
Gene Ontology (GO)
Pathways
• N-terminal acetylation (Reactome: R-HSA-1234158)
• NatA complex (Reactome: R-HSA-1234150)
Protein Summary
NAA16 is a 866-amino acid protein that functions as an auxiliary subunit of the NatA complex. It contains a conserved N-terminal domain that mediates interaction with the catalytic subunit NAA10. NAA16 is thought to influence substrate selection and may have a role in cellular stress responses. The protein is localized predominantly in the cytoplasm.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NAA16 Knockout HEK293 Cell Line | EDJ-KQ14355 | Human | 79612 | Details Get a Quote |
| NAA16 Knockout A-549 Cell Line | EDJ-KQ44474 | Human | 79612 | Details Get a Quote |
| NAA16 Knockout HCT 116 Cell Line | EDJ-KQ44475 | Human | 79612 | Details Get a Quote |
| NAA16 Knockout HeLa Cell Line | EDJ-KQ44476 | Human | 79612 | Details Get a Quote |
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